孤儿核受体蛋白Nur77抗体

英文名称Nur77中文名称孤儿核受体蛋白Nur77抗体别    名GFRP 1; GFRP; GFRP1; Growth factor inducible nuclear protein N10; Growth Factor Inducible Nuclear Protein NP10; Growth Factor Response Protein 1; Hbr1; HMR; Hormone Receptor; MGC9485; N10; N10 nuclear protein; NAK 1; NAK1; NGFIB; NP 10; NP10; NR4A1; Nuclear hormone receptor NUR/77; Nuclear Hormone Receptor TR3; Nuclear Receptor Subfamily 4 Group A Member 1; NUR77; Orphan nuclear receptor HMR; Orphan nuclear receptor NR4A1; ST 59; ST59; Steroid receptor TR3; TR 3; TR3; TR3 orphan receptor; Early response protein NAK1.  研究领域肿瘤  细胞生物  免疫学  染色质和核信号  神经生物学  信号转导  细胞凋亡  转录调节因子  糖尿病  抗体来源Rabbit克隆类型Polyclonal交叉反应Human, Mouse, Rat,  (predicted: Dog, Cow, Horse, )产品应用WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=3ug/test IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.分 子 量66kDa细胞定位细胞核 性    状Liquid浓    度1mg/ml免 疫 原KLH conjugated synthetic peptide derived from human Nur77/GFRP:351-450/598 亚    型IgG纯化方法affinity purified by Protein A储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.保存条件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.PubMedPubMed产品介绍This gene encodes a member of the steroid-thyroid hormone-retinoid receptor superfamily. Expression is induced by phytohemagglutinin in human lymphocytes and by serum stimulation of arrested fibroblasts. The encoded protein acts as a nuclear transcription factor. Translocation of the protein from the nucleus to mitochondria induces apoptosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2011]

Subunit:
Binds DNA as a monomer (By similarity). Interacts with GADD45GIP1.

Subcellular Location:
Nucleus.

Tissue Specificity:
Fetal muscle and adult liver, brain and thyroid.

Similarity:
Belongs to the nuclear hormone receptor family. NR4 subfamily.
Contains 1 nuclear receptor DNA-binding domain.

SWISS:
P22736

Gene ID:
3164

Database links:

Entrez Gene: 3164 Human

Entrez Gene: 15370 Mouse

Entrez Gene: 79240 Rat

Omim: 139139 Human

SwissProt: P22736 Human

SwissProt: P12813 Mouse

SwissProt: P22829 Rat

Unigene: 524430 Human

Unigene: 119 Mouse

Unigene: 10000 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

孤儿核受体蛋白Nur77是早期反应转录因子之一，多种刺激因子如缺氧可诱导其迅速表达，Nur77参与调控细胞增殖、存活、分化等过程。这类核受体是体内广泛分布的配体依赖性的转录因子，通过调控基因协调表达，在机体的生长发育、新陈代谢，细胞分化及体内许多生长发育过程中发挥重要作用，其功能障碍将导致一系列疾病的发生，如；癌症、糖尿病、肥胖、不孕不育等等。