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- Biorigin
- BN41595R
- 2025年08月10日
- WB,
- Human,Mouse,Rat,
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- 详细信息
- 文献和实验
- 技术资料
- 适应物种：
Human,Mouse,Rat,
- 应用范围：
WB,
- 抗体英文名：
CD144/VE Cadherin
- 规格：
50ul
| 英文名称 | CD144/VE Cadherin |
| 中文名称 | 血管内皮钙粘蛋白抗体 |
| 别 名 | VE-cadherin; 7B4 antigen; VECD; Vascular endothelial cell cadherin; 7B 4; 7B4; 7B4 antigen; Cadherin 5; Cadherin 5 type 2; Cadherin-5; Cadherin5; CD 144; CD144 antigen; CDH 5; CDH5; CDH5 protein; Vascular endothelial cadherin; VE Cad antibody VEC; CADH5_HUMAN. |
| 研究领域 | 肿瘤 心血管 免疫学 信号转导 细胞粘附分子 血管内皮细胞 上皮细胞 内皮细胞 细胞外基质 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, |
| 产品应用 | ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1μg /test ICC=1:100 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 86kDa |
| 细胞定位 | 细胞膜 |
| 性 状 | Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from mouse Vascular endothelial cell cadherin:601-700/784 <Cytoplasmic> |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
| PubMed | PubMed |
| 产品介绍 | This gene is a classical cadherin from the cadherin superfamily and is located in a six-cadherin cluster in a region on the long arm of chromosome 16 that is involved in loss of heterozygosity events in breast and prostate cancer. The encoded protein is a calcium-dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Functioning as a classic cadherin by imparting to cells the ability to adhere in a homophilic manner, the protein may play an important role in endothelial cell biology through control of the cohesion and organization of the intercellular junctions. An alternative splice variant has been described but its full length sequence has not been determined. [provided by RefSeq, Jul 2008]. Function: Cadherins are calcium dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. This cadherin may play a important role in endothelial cell biology through control of the cohesion and organization of the intercellular junctions. It associates with alpha-catenin forming a link to the cytoskeleton. Acts in concert with KRIT1 to establish and maintain correct endothelial cell polarity and vascular lumen. These effects are mediated by recruitment and activation of the Par polarity complex and RAP1B. Required for activation of PRKCZ and for the localization of phosphorylated PRKCZ, PARD3, TIAM1 and RAP1B to the cell junction. Subunit: Interacts via cadherin 5 domain with PTPRB. Interacts with TRPC4. Interacts with KRIT1. Subcellular Location: Cell junction. Cell membrane. Found at cell-cell boundaries and probably at cell-matrix boundaries. Tissue Specificity: Endothelial tissues and brain. Post-translational modifications: Phosphorylated on tyrosine residues by KDR/VEGFR-2. Dephosphorylated by PTPRB. Similarity: Contains 5 cadherin domains. SWISS: P55284 Gene ID: 12562 Database links: Entrez Gene: 1003 Human Entrez Gene: 12562 Mouse Omim: 601120 Human SwissProt: P33151 Human SwissProt: P55284 Mouse Unigene: 76206 Human Unigene: 21767 Mouse Unigene: 224644 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 血管内皮钙粘蛋白(Vascularendothelial cell cadherin;VE-cadherin;VECD),又名CD144,Cadherin-5,是AJ连接（粘附连接）的主要粘附分子,是维持血管内皮细胞极性和完整性必不可少的内皮细胞特异性钙粘蛋白 |
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文献和实验人 血管内皮钙粘蛋白 ( VE-Ca ) 酶联免疫分析（ELISA ） 试剂盒使用说明书 本试剂仅供研究使用 目的：本试剂盒用于测定人血清，血浆及相关液体样本 中 血管内皮钙粘蛋白 (VE-Ca) 的含量。 实验原理： 本试剂盒应用双抗体夹心法测定标本中 人 血管内皮钙粘蛋白 ( VE-Ca ) 水平。用纯化的 人 血管内皮钙粘蛋白 ( VE-Ca ) 抗体 包被微孔板，制成固相抗体，往包被单抗的微孔中依次加入血管内皮钙粘
一、流体剪切力细胞实验背景液体是每个生物物种的重要组成部分。在生理状态下，许多细胞类型被流体环境包围。典型例子包括：血管内皮细胞，形成血管内层，淋巴管内皮细胞，形成淋巴管内层，肾和肺的上皮细胞。这种液体流动引起剪切应力，这是一种机械力，以多种方式影响细胞形态和行为。在许多标准体外实验中，细胞在没有流动的情况下培养。在这些静态条件下，通常没有考虑剪切应力依赖性细胞变化。实际上，在流动下的体外细胞培养并模拟这种机械刺激并诱导更加接近生理状态的体内生物过程行为很有意义。特别对于研究在生物流体中存在
PriCells: 原代血管内皮细胞、Angiogenesis、VEGF
之一。微血管对蛋白的通透性的增加是血管形成的关键。血浆蛋白的漏出和血管外纤维蛋白基质的形成为内皮细胞生长、迁移所必需的。VEGF在血管新生中起重要作用：（1） VEGF通过增强小血管内皮细胞内的囊泡、细胞器、囊状结构的活性来促进血管腔内和腔外血浆成分代谢，以及通过对钙粘蛋白/链蛋白复合体的作用使单层内皮细胞之间的粘附连接松解，从而提高循环代谢中小血管通透性。血管通透性增加可使血浆蛋白外渗并形成细胞外基质，引起内皮细胞和基质细胞的转移。（2） VEGF刺激内皮细胞产生纤溶酶原激活物(uPA和tPA)、纤溶
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