万千商家帮你免费找货
0 人在求购买到急需产品
- 详细信息
- 文献和实验
- 技术资料
- 适应物种:
Human,Mouse,Rat,Chicken,Dog,Pig,Cow,Horse,Guinea Pig,
- 应用范围:
WB,
- 抗体英文名:
STK38
- 规格:
100ul
| 英文名称 | STK38 |
| 中文名称 | 丝氨酸/苏氨酸蛋白激酶38抗体 |
| 别 名 | NDR 1; NDR1; NDR1 protein kinase; Nuclear Dbf2 related kinase 1; Serine/threonine protein kinase 38; STK 38; STK-38; STK38_HUMAN. |
| 研究领域 | 肿瘤 细胞生物 免疫学 信号转导 激酶和磷酸酶 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, (predicted: Rat, Chicken, Dog, Pig, Cow, Horse, Guinea Pig, ) |
| 产品应用 | WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 (石蜡切片需做抗原修复) not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 51kDa |
| 细胞定位 | 细胞核 细胞浆 |
| 性 状 | Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human STK38:31-130/465 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
| PubMed | PubMed |
| 产品介绍 | STK38 belongs to the NDR family of serine/threonine protein kinases. NDR kinases require the phosphorylation of conserved Ser/Thr residues for activation. NDR family members have two unique stretches of primary sequence: an N-terminal regulatory (NTR) domain and an insert of several residues between subdomains VII and VIII of the kinase domain. The kinase domain insert functions as an auto-inhibitory sequence (AIS), while binding of the co-activator MOB (Mps-one binder) proteins to the NTR domain releases NDR kinases from inhibition of autophosphorylation. STK38 negatively regulates the activation of MEKK1/2 by direct interaction with the catalytic domain of MEKK1/2. The negative regulation of MEKK1/2 is not due to its phosphorylation by STK38. Function: Negative regulator of MAP3K1/2 signaling. Converts MAP3K2 from its phosphorylated form to its nonphosphorylated form and inhibits autophosphorylation of MAP3K2. Subunit: Homodimeric S100B binds two molecules of STK38. Subcellular Location: Nucleus. Cytoplasm. Tissue Specificity: Ubiquitously expressed with highest levels observed in peripheral blood leukocytes. Post-translational modifications: ISGylated (Probable). Phosphorylated by STK3/MST2 and this is enhanced by MOBKL1B. Similarity: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. Contains 1 AGC-kinase C-terminal domain. Contains 1 protein kinase domain. SWISS: Q15208 Gene ID: 11329 Database links: Entrez Gene: 11329 Human Entrez Gene: 106504 Mouse Omim: 606964 Human SwissProt: Q15208 Human SwissProt: Q91VJ4 Mouse Unigene: 409578 Human Unigene: 439986 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |


风险提示:丁香通仅作为第三方平台,为商家信息发布提供平台空间。用户咨询产品时请注意保护个人信息及财产安全,合理判断,谨慎选购商品,商家和用户对交易行为负责。对于医疗器械类产品,请先查证核实企业经营资质和医疗器械产品注册证情况。
文献和实验的研究已经成为蛋白质科学的热点之一。 磷酸化多肽(主要指肽链中的酪氨酸、丝氨酸和苏氨酸残基的侧链羟基被磷酸化生成酸式磷酸酯的修饰多肽)是研究蛋白质磷酸化过程的必不可少的工具,它可作为磷酸酶模型底物,或作为可产生抗磷酸化蛋白抗体的抗原,也可以在确定磷酸化蛋白的物理参数时作为参考化合物等[3]。因此磷酸化多肽的合成在过去的几年中吸引了相当大的兴趣,目前已确定了较为成熟的合成路线,使磷酸化多肽的合成趋于常规。目前磷酸化多肽的合成主要有两个策略:后磷酸化法(Global
。如果你研究的蛋白激酶恰好既不是 AMPK 也不是 AKT,那该怎么办呢?办法还是有的。下面就以当前研究得如火如荼的蛋白激酶 mTORC1 为例。mTORC1 是一类丝氨酸 / 苏氨酸蛋白激酶复合物,在细胞增殖、细胞代谢和细胞自噬等生物学过程中发挥重要的调控作用。关于 mTORC1 的研究虽然火热,但目前市面上并没有可用的针对其底物的泛磷酸化抗体。好在 mTORC1 偏好的底物蛋白序列已经由 David Sabatini 实验室在 2011 年的一篇《Science》论文中予以揭示。David
P38MAPK 信号转导通路 分裂原激活的蛋白 激酶(mitogen activated protein kinases,MAPK)家族是非常保守的丝氨酸/苏氨酸蛋白激酶,是信号转导过程中一组主要的信号分子,在发育和疾病发生过程中起重要作用。该家族有4个成员,即细胞外信号调节激酶(extracellular regulated proteinhnase l/2,ERK 1/2),c―jun N端激酶(c―jun N―terminal kinase,JNK)/应急激活的蛋白激酶
技术资料暂无技术资料 索取技术资料




