UM-UC-3、UM-UC-3、UM-UC-3细胞、UM-U

UM-UC-3、UM-UC-3、UM-UC-3细胞、UM-UC-3细胞、UM-UC-3人膀胱移行细胞癌细胞

Cell line name UM-UC-3

Synonyms UMUC-3; UM-UC3; UMUC3; UC-3; University of Michigan-Urothelial Carcinoma-3

Accession CVCL_1783

Resource Identification Initiative To cite this cell line use: UM-UC-3 (RRID:CVCL_1783)

Comments Part of: BLA-40 bladder carcinoma cell line panel.

Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).

Part of: COSMIC cell lines project.

Part of: UBC-40 urothelial bladder cancer cell line index.

Population: Caucasian.

Doubling time: 24 hours (PubMed=3761468).

Microsatellite instability: Stable (MSS) (Sanger).

Omics: CNV analysis.

Omics: Deep exome analysis.

Omics: Deep quantitative proteome analysis.

Omics: DNA methylation analysis.

Omics: GPI-anchored proteins analysis by proteomics.

Omics: SNP array analysis.

Omics: Transcriptome analysis by microarray.

Omics: Transcriptome analysis by RNAseq.

Derived from site: In situ; Urinary bladder; UBERON=UBERON_0001255.

PubMed=12068308; DOI=10.1038/nature00766

Davies H.R., Bignell G.R., Cox C., Stephens P.J., Edkins S., Clegg S., Teague J.W., Woffendin H., Garnett M.J., Bottomley W., Davis N., Dicks E., Ewing R., Floyd Y., Gray K., Hall S., Hawes R., Hughes J., Kosmidou V., Menzies A., Mould C., Parker A., Stevens C., Watt S., Hooper S., Wilson R., Jayatilake H., Gusterson B.A., Cooper C.S., Shipley J.M., Hargrave D., Pritchard-Jones K., Maitland N.J., Chenevix-Trench G., Riggins G.J., Bigner D.D., Palmieri G., Cossu A., Flanagan A.M., Nicholson A., Ho J.W.C., Leung S.Y., Yuen S.T., Weber B.L., Seigler H.F., Darrow T.L., Paterson H.F., Marais R., Marshall C.J., Wooster R., Stratton M.R., Futreal P.A.

Mutations of the BRAF gene in human cancer.

Nature 417:949-954(2002)

 

PubMed=12127398; DOI=10.1016/S0165-4608(01)00648-3

Strefford J.C., Lillington D.M., Steggall M., Lane T.M., Nouri A.M.E., Young B.D., Oliver R.T.D.

Novel chromosome findings in bladder cancer cell lines detected with multiplex fluorescence in situ hybridization.

Cancer Genet. Cytogenet. 135:139-146(2002)

 

PubMed=15846775; DOI=10.1002/gcc.20166

Williams S.V., Adams J., Coulter J., Summersgill B.M., Shipley J.M., Knowles M.A.

Assessment by M-FISH of karyotypic complexity and cytogenetic evolution in bladder cancer in vitro.

Genes Chromosomes Cancer 43:315-328(2005)

 

PubMed=16469639; DOI=10.1016/S0022-5347(05)00323-X

Sabichi A.L., Keyhani A., Tanaka N., Delacerda J., Lee I.-L., Zou C.-P., Zhou J.-H., Benedict W.F., Grossman H.B.

Characterization of a panel of cell lines derived from urothelial neoplasms: genetic alterations, growth in vivo and the relationship of adenoviral mediated gene transfer to coxsackie adenovirus receptor expression.

J. Urol. 175:1133-1137(2006)

 

PubMed=18812553; DOI=10.1093/jnci/djn304; PMCID=PMC2720731

Park H.-S., Park W.S., Bondaruk J., Tanaka N., Katayama H., Lee S., Spiess P.E., Steinberg J.R., Wang Z., Katz R.L., Dinney C.P.N., Elias K.J., Lotan Y., Naeem R.C., Baggerly K., Sen S., Grossman H.B., Czerniak B.

Quantitation of Aurora kinase A gene copy number in urine sediments and bladder cancer detection.

J. Natl. Cancer Inst. 100:1401-1411(2008)

 

PubMed=19375735; DOI=10.1016/j.juro.2009.01.108; PMCID=PMC2680455

Chiong E., Dadbin A., Harris L.D., Sabichi A.L., Grossman H.B.

The use of short tandem repeat profiling to characterize human bladder cancer cell lines.

J. Urol. 181:2737-2748(2009)

 

PubMed=20164919; DOI=10.1038/nature08768; PMCID=PMC3145113

Bignell G.R., Greenman C.D., Davies H.R., Butler A.P., Edkins S., Andrews J.M., Buck G., Chen L., Beare D., Latimer C., Widaa S., Hinton J., Fahey C., Fu B.-Y., Swamy S., Dalgliesh G.L., Teh B.T., Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.

Signatures of mutation and selection in the cancer genome.

Nature 463:893-898(2010)

 

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458; PMCID=PMC2881662

Rothenberg S.M., Mohapatra G., Rivera M.N., Winokur D., Greninger P., Nitta M., Sadow P.M., Sooriyakumar G., Brannigan B.W., Ulman M.J., Perera R.M., Wang R., Tam A., Ma X.-J., Erlander M., Sgroi D.C., Rocco J.W., Lingen M.W., Cohen E.E.W., Louis D.N., Settleman J., Haber D.A.

A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.

Cancer Res. 70:2158-2164(2010)