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文献和实验Serum Low-Molecular-Weight Protein Fractionation for Biomarker Discovery
, and cerebrospinal fluid. Unfortunately, discovering and validating protein biomarkers are hindered by the presence of high-molecular-weight proteins, such as serum albumin and immunoglobulins, which comprise 90% of the proteins present in these samples. High
Grade Disodiumfluorescein was from Exction, Inc. Low molecular weight (13,000–23,000 MW) poly(vinyl alcohol) (PVA) was from Aldrich. Fluorescein-doped PVA samples were prepared on 1 × 1 in. microscope cover slips, either SIF coated or with SACS prepared
Targeting Cancer with Small-Molecular-Weight Kinase Inhibitors
Protein and lipid kinases fulfill essential roles in many signaling pathways that regulate normal cell functions. Deregulation of these kinase activities lead to a variety of pathologies ranging from cancer to inflammatory diseases, diabetes
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