- ￥550 - 2300
- MedChemExpress(MCE)
- 美国
- HY-15258
- 2025年12月05日
企业认证
相关产品推荐更多 >
万千商家帮你免费找货
0 人在求购买到急需产品
- 详细信息
- 技术资料
- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 英文名：
RDEA594
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
878672-00-5
- 规格：
10 mM * 1 mL/5 mg/10 mg/50 mg/100 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥605.0 |
|---|---|---|---|
| 规格： | 5 mg | 产品价格： | ￥550.0 |
| 规格： | 10 mg | 产品价格： | ￥700.0 |
| 规格： | 50 mg | 产品价格： | ￥1900.0 |
| 规格： | 100 mg | 产品价格： | ￥2300.0 |
MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。
Lesinurad
CAS No. : 878672-00-5
MCE 国际站：Lesinurad
产品活性：Lesinurad 是一种 URAT1 和 OAT 抑制剂，用作肾转运蛋白OAT1 和OAT3 的底物，Km值分别为 0.85 和 2 μM。
研究领域：Membrane Transporter/Ion Channel
作用靶点：URAT1
In Vitro: Lesinurad is a novel selective uric acid reabsorption inhibitor (SURI). Lesinurad is determined to be a substrate for the kidney transporters organic anion transporter (OAT1) and OAT3 with Km values of 0.85 and 2 μM, respectively. Lesinurad (RDEA594) is a URAT1 and OAT inhibitor, which increases proximal renal tubule urate excretion. Lesinurad (RDEA594) is a potential uric acid lowering agent througn inhibition of uric acid reuptake, and exhibits favorable p450 profiles, inhibits CYP2C9 and CYP2C8 with IC50 of 14.4 μM and 16.2 μM, respectively. IC50s of Lesinurad are all above 100 μM for CYP1A2, CYP2C19,and CYP2D6.
In Vivo: Lesinurad (RDEA594) shows better pharmacokinetics than its pro-drug RDEA806. The 100 mg dose of Lesinurad exhibits a phamacological effect in the range of that produced by 300 mg to 800 mg single doses of RDEA806.
相关产品：Drug Repurposing Compound Library Plus | FDA-Approved Drug Library Plus | FDA-Approved Drug Library Mini | Bioactive Compound Library Plus | Membrane Transporter/Ion Channel Compound Library | FDA-Approved Drug Library | Drug Repurposing Compound Library | Orally Active Compound Library | FDA Approved & Pharmacopeial Drug Library | Drug-Induced Liver Injury (DILI) Compound Library | EMA-Approved Drug Library | Membrane Protein-targeted Compound Library | Membrane Receptor-targeted Compound Library | Verinurad | Lesinurad sodium | Benzarone | Epaminurad | Ruzinurad | Xininurad | KPH2f | URAT1 inhibitor 1 | Lingdolinurad | Puliginurad | URAT1 inhibitor 2 | URAT1 inhibitor 3 | URAT1 inhibitor 4 | URAT1 inhibitor 5 | URAT1 inhibitor 6 | URAT1 inhibitor 7 | URAT1 inhibitor 8 | URAT1&XO inhibitor 1 | URAT1&XO inhibitor 2
热门产品线：重组蛋白 | 化合物库 | 天然产物 | 荧光染料 | PROTAC | 同位素标记物
Trending products：Recombinant Proteins | Bioactive Screening Libraries | Natural Products | Dye Reagents | PROTAC | Isotope-Labeled Compounds
风险提示：丁香通仅作为第三方平台，为商家信息发布提供平台空间。用户咨询产品时请注意保护个人信息及财产安全，合理判断，谨慎选购商品，商家和用户对交易行为负责。对于医疗器械类产品，请先查证核实企业经营资质和医疗器械产品注册证情况。
技术资料暂无技术资料 索取技术资料
