FNDR-20123

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FNDR-20123

CAS No. : 2641930-61-0

MCE 国际站：FNDR-20123

产品活性：FNDR-20123 是一种有效、安全、首创的抗疟疾 HDAC 抑制剂，对疟原虫和人类 HDAC 的 IC₅₀ 分别为 31 nM 和 3 nM。FNDR-20123 对恶性疟原虫 (Plasmodium falciparum) 无性期 (IC₅₀=41 nM) 和性血期 (雄性配子体 IC₅₀=190 nM) 具有抗疟疾活性。FNDR-20123 抑制 HDAC1，HDAC2，HDAC3，HDAC6，HDAC8 的 IC₅₀ 分别为 25，29，2，11，282 nM，并在纳摩尔浓度下抑制 III 类 HDAC 亚型。

研究领域：Cell Cycle/DNA Damage  |  Epigenetics  |  Anti-infection

作用靶点：HDAC  |  Parasite

In Vitro: FNDR-20123 is active against all resistant strains tested so far, which will be highly valuable in eliminating the rapidly evolving drug-resistant parasite.

In Vivo: FNDR-20123 (10-50 mg/kg; p.o.; bw for 4 days) is also able to reduce parasitaemia significantly in a mouse model for P. falciparum infection.

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