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- 2025年12月05日
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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
2448173-47-3
- 规格：
10 mM * 1 mL/1 mg/5 mg/10 mg/25 mg/50 mg/100 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥1403.0 |
|---|---|---|---|
| 规格： | 1 mg | 产品价格： | ￥431.0 |
| 规格： | 5 mg | 产品价格： | ￥1041.0 |
| 规格： | 10 mg | 产品价格： | ￥1725.0 |
| 规格： | 25 mg | 产品价格： | ￥2913.0 |
| 规格： | 50 mg | 产品价格： | ￥4163.0 |
| 规格： | 100 mg | 产品价格： | ￥5863.0 |
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Menin-MLL inhibitor 20
CAS No. : 2448173-47-3
MCE 国际站：Menin-MLL inhibitor 20
产品活性：Menin-MLL inhibitor 20 是一种不可逆的 menin-MLL 相互作用的抑制剂，具有抗肿瘤活性 (WO2020142557A1, Intermediate 6)。
研究领域：Epigenetics
作用靶点：Epigenetic Reader Domain
In Vitro: The Histone-lysine N-methyltransferase 2 (KMT2) family of proteins, which currently consists of at least 5 members, methylate ly sine 4 on the histone H3 tails at important regulatory regions in the genome and thereby impart crucial functions through the modulation of chromatin structures and DNA accessibility. These enzymes are known to play an important role in the regulation of gene expression during early development and hematopoiesis. The human KMT2 family was initially named the mixed-lineage leukaemia (MLL) family, owing to the role of the first-found member in this disease.
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文献和实验Combined 3C-ChIP-Cloning (6C) Assay: A Tool to Unravel Protein-Mediated Genome Architecture
:chloroform:isoamyl alcohol, UltraPure (25:24:1 v/v/v; Invitrogen) Phosphate-buffered saline (PBS; GIBCO 20012) Protease inhibitor cocktail (Sigma P8340) Proteinase K (10 mg/mL in TE buffer, pH 8.0; Invitrogen) PureLink HQ 96 Mini
卵巢癌（Ovarian Cancer）是最具破坏性的妇科癌症，目前 5 年总生存率低至 47%【1】。卵巢癌是一种高度异质性疾病，通常根据组织病理学、分子生物学和遗传学分析的结果，将卵巢癌分为两大类：I 型卵巢癌病情进展缓慢，主要为低级别浆液性癌（LGSC），粘液癌，子宫内膜样癌，透明细胞癌等；II 型癌症则进展迅速，主要为高级别浆液性癌（HGSC）、未分化癌和癌细胞瘤。 治疗卵巢癌的标准方式是手术切除和铂-紫杉醇化疗相结合，然而这类化疗方式往往对于透明细胞癌和粘液癌患者无效
A Modified Protocol for Bisulfite Genomic Sequencing of Difficult Samples
in one fully methylated cell line, H-596, treated or not with 5-azadeoxycytidine, a methylation inhibitor. We believe that this method may easily be adapted for analyzing other genes and provide guidelines for selecting the most appropriate MRED restriction
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