- ￥1400 - 13500
- MedChemExpress(MCE)
- 美国
- HY-P9924
- 2025年12月05日
企业认证
相关产品推荐更多 >
万千商家帮你免费找货
0 人在求购买到急需产品
- 详细信息
- 技术资料
- 保存条件：
Please store the product under the recommended conditions in the Certificate of Analysis.
- 英文名：
LY2439821
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
1143503-69-8
- 规格：
1 mg/5 mg/10 mg/25 mg/50 mg
| 规格： | 1 mg | 产品价格： | ￥1400.0 |
|---|---|---|---|
| 规格： | 5 mg | 产品价格： | ￥4650.0 |
| 规格： | 10 mg | 产品价格： | ￥6750.0 |
| 规格： | 25 mg | 产品价格： | ￥10000.0 |
| 规格： | 50 mg | 产品价格： | ￥13500.0 |
MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。
Ixekizumab
CAS No. : 1143503-69-8
MCE 国际站：Ixekizumab
产品活性：Ixekizumab 是一种人源化 IgG4 单克隆抗体，可选择性结合和中和白细胞介素 IL-17A (KD<3 pM)。Ixekizumab 直接阻断 IL-17A 与 IL-17RA 的结合，但不与其他 IL-17 家族成员结合。Ixekizumab 用于中重度斑块型银屑病的研究。
作用靶点：Interleukin Related
In Vitro: The equilibrium KD of Ixekizumab for human and cynomolgus monkey IL-17A were 1.8 pM and 0.8 pM, respectively. Ixekizumab also bound to rabbit IL-17A, but the affinity was lower, and the binding was heterogeneous (KD of 1.3 nM and 14 nM). Ixekizumab shows no binding to either mouse or rat IL-17A.
Ixekizumab (0.1-10000 pM) inhibits human IL-17A- or human IL-17A/F heterodimer-induced growth-regulated oncogene (GRO)α secretion from HT-29 cells in a dose-dependent fashion. Ixekizumab inhibits cynomolgus monkey IL-17A-induced GROα secretion from HT-29 cells in a dose-dependent fashion.
In Vivo: Ixekizumab (0.001-1 mg/kg; i.v.) is able to decrease human IL-17A-induced keratinocyte chemoattractant (KC) secretion in the plasma of the C57BL/6 mice in a dose-dependent manner.
In male cynomolgus monkeys, following IV administration of 1 mg/kg, Ixekizumab is eliminated with a mean half-life of 6.5 days. After SC administration of 1 mg/kg, Ixekizumab reaches an average maximal plasma concentration of 11.1 µg/mL ~72 hours postdose. The mean elimination half-life following the SC injection was 10.3 days.
相关产品：Resatorvid | Disulfiram | Polyinosinic-polycytidylic acid | Deucravacitinib | Raleukin | Apilimod | Tocilizumab | Oxidopamine hydrobromide | Dupilumab | Theophylline | LMT-28 | Secukinumab | Clofazimine | Benzbromarone | Sodium metatungstate | Hydrocortisone hemisuccinate | SC144 | Diacerein | Muscone | JTE-607 | IL-17A inhibitor 1 | APY0201 | Vidofludimus | Prednisone acetate | Semapimod tetrahydrochloride | ODN 2216 | Triamcinolone | IL-17A antagonist 1
热门产品线：重组蛋白 | 化合物库 | 天然产物 | 荧光染料 | PROTAC | 同位素标记物
Trending products：Recombinant Proteins | Bioactive Screening Libraries | Natural Products | Dye Reagents | PROTAC | Isotope-Labeled Compounds
风险提示：丁香通仅作为第三方平台，为商家信息发布提供平台空间。用户咨询产品时请注意保护个人信息及财产安全，合理判断，谨慎选购商品，商家和用户对交易行为负责。对于医疗器械类产品，请先查证核实企业经营资质和医疗器械产品注册证情况。
技术资料暂无技术资料 索取技术资料
