Atuliflapon,2041075-86-7

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Atuliflapon

CAS No. : 2041075-86-7

MCE 国际站：Atuliflapon

产品活性：Atuliflapon (AZD5718) 是具有口服活性的 FLAP (5 -脂氧合酶激活蛋白) 的抑制剂，其 IC₅₀ 值为 2 nM。Atuliflapon 可用于冠状动脉疾病的研究。

研究领域：Immunology/Inflammation

作用靶点：FLAP

In Vitro: Atuliflapon demonstrates a dose dependent and greater than 90% suppression of leukotriene production over 24 h.
?Atuliflapon exhibits an IC₅₀ of 39 nM for LTB₄.

In Vivo: Atuliflapon exhibits t1/2 of 0.45 h and 2.1 h in rat and dog by iv injection, respectively.
?Atuliflapon shows no inhibition of 5-LO pathway activity in rodent blood.

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