Ucf-101,313649-08-0

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Ucf-101

CAS No. : 313649-08-0

MCE 国际站：Ucf-101

产品活性：Ucf-101 是一种选择性和竞争性的促凋亡蛋白酶 Omi/HtrA2 抑制剂，抑制 His-Omi 的 IC₅₀ 值为 9.5 μM。Ucf-101 对各种其他丝氨酸蛋白酶的活性极低 (IC₅₀>200 μM)。Ucf-101 在 543 nm 处具有天然的红色荧光，可用于监视其进入哺乳动物细胞的能力。Ucf-101 对 MI/R 损伤具有明显的心脏保护作用，并且还具有一定的神经保护作用。

研究领域：Apoptosis

作用靶点：Apoptosis

In Vitro: Ucf-101 (20-100 μM; 30 min) inhibits the proteolytic activity of MBP-Omi-(134-458).
?Ucf-101 (10-100 μM; pretreated for 10 min) inhibits His-Omi-(134-458) activity in a concentration-dependent manner when assayed with His-Omi-(134-458) and β-casein.
?Ucf-101 (1-25 μM; 36 h) inhibits Omi-induced caspase-independent apoptosis of mouse embryo caspase-9 (-/-) null fibroblasts.
?Ucf-101 (1-20 μM; pretreated for 1 h) inhibits the 6-OHDA-induced apoptosis of Parkinson’s disease (PD)-PC12 cells at the low concentration (2.5 μM), and increases the apoptosis rate at the high concentration (≥10 μM).
?Ucf-101 (2.5 μM; pretreated for 1 h) downregulates the expression of Glucose-regulated protein 78 (Bip/Grp78) and C/EBP homologous protein (CHOP) in PD- PC12 cells.

In Vivo: Ucf-101 (0.6-1.8 μmol/kg; a single i.p.) reduces postischemic myocardial apoptosis and myocardial infarct size in mice.
?Ucf-101 (1.5 μmol/kg; a single i.p.) improves the APO-induced rotational behavior, increases the TH-positive cells and reverses the reduction of DA neurons in the PD rats.

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