ACH-000143,2225836-30-4

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

ACH-000143

CAS No. : 2225836-30-4

MCE 国际站：ACH-000143

产品活性：ACH-000143 是有效的、具有口服活性的褪黑素受体的激动剂，对MT1 和MT2 的EC₅₀ 值分别为0.06 nM 和0.32 nM。

研究领域：GPCR/G Protein  |  Neuronal Signaling

作用靶点：Melatonin Receptor

In Vivo: ACH-000143 reduces liver triglycerides and steatosis in diet-Induced obese rats.
ACH-000143 is devoid of hERG binding, genotoxicity, and behavioral alterations at doses up to 100 mg/kg p.o., supporting further investigation of this compound as a drug candidate.
ACH-000143 significantly reduces plasma glucose at 10 mg/kg (−16.4%, p < 0.05) and 30 mg/kg (−16.9%, p < 0.01).

相关产品：Bioactive Compound Library Plus  |  GPCR/G Protein Compound Library  |  Neuronal Signaling Compound Library  |  Orally Active Compound Library  |  Targeted Diversity Library  |  Membrane Protein-targeted Compound Library  |  Membrane Receptor-targeted Compound Library  |  Melatonin  |  Luzindole  |  4-P-PDOT  |  Ramelteon  |  Agomelatine  |  S26131  |  2-Iodomelatonin  |  Tasimelteon  |  8-M-PDOT  |  Piromelatine  |  UCM 608  |  Ramelteon metabolite M-II-d3  |  N-Acetyltryptamine  |  6-Chloromelatonin  |  7-Desmethyl-3-hydroxyagomelatine  |  Antidepressant agent 3  |  Antidepressant agent 4  |  DH97  |  GR 128107  |  GR 196429  |  Melatonin receptor agonist 1

热门产品线：重组蛋白  |  化合物库  |  天然产物  |  荧光染料  |  PROTAC  |  同位素标记物

Trending products：Recombinant Proteins  |  Bioactive Screening Libraries  |  Natural Products  |  Dye Reagents  |  PROTAC  |  Isotope-Labeled Compounds