MMPIP,479077-02-6

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MMPIP

CAS No. : 479077-02-6

MCE 国际站：MMPIP

产品活性：MMPIP 是一种变构的选择性代谢型谷氨酸受体7 (mGluR7) 拮抗剂 (K_B 值范围为 24-30 nM)。 MMPIP 可用于研究 mGluR7 对中枢神经系统功能的作用。MMPIP 可减轻神经病小鼠的疼痛并使其情感和认知行为正常化。

研究领域：GPCR/G Protein  |  Neuronal Signaling

作用靶点：mGluR

In Vitro: MMPIP inhibits L-(+)-2-amino-4-phosphonobutyric acid (L-AP4; 0.5 mM)-induced intracellular Ca²⁺ mobilization in Chinese hamster ovary (CHO) cells coexpressing rat mGluR7 with G_α15 (IC5₅₀=26 nM) .
In CHO cells expressing rat mGluR7, MMPIP inhibits L-AP4-induced inhibition of forskolin-stimulated cAMP accumulation (IC₅₀ 220 nM).
MMPIP also antagonizes L-AP4-induced inhibition of cAMP accumulation with an IC₅₀ of 610 nM in CHO-human mGluR7/G_α15.

In Vivo: MMPIP (10 mg/kg) attenuates the amplitude of the acoustic startle response and markedly enhances the prepulse-induced inhibition of the acoustic startle response (up to 137% of control).
MMPIP (10 mg/kg) rescues the MK-801 (0.1 mg/kg)-induced cognitive impairments, by improving the choice accuracy.
Zamifenacin exhibits short elimination half-lives (plasma 1.16 h, brain 1.75 h) following i.p. administration (10 mg/kg) in mice.

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