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- 2025年12月05日
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- 详细信息
- 技术资料
- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 英文名：
INO-8875
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
871108-05-3
- 规格：
10 mM * 1 mL/1 mg/5 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥4400.0 |
|---|---|---|---|
| 规格： | 1 mg | 产品价格： | ￥1818.0 |
| 规格： | 5 mg | 产品价格： | ￥4000.0 |
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Trabodenoson
CAS No. : 871108-05-3
MCE 国际站：Trabodenoson
产品活性：Trabodenoson (INO-8875) 是一种腺苷模拟物，是高选择性的腺苷 A1 受体 (Adenosine A1 receptor) 的激动剂。Trabodenoson (INO-8875) 可用于原发性开角型青光眼的研究。
研究领域：GPCR/G Protein
作用靶点：Adenosine Receptor
In Vitro: Trabodenoson treatment significantly increaseS MMP-2 activity and MMP-14 abundance, while decreasing fibronectin and collagen IV expression.
In Vivo: Trabodenoson (6.0%), demonstrating an average IOP drop of 2.45 ± 0.38 mm Hg in young mice over 7 days (downregulation).
Topical trabodenoson significantly upregulates nestin expression in the ONH of induced eyes compared with vehicle-treated no-induced eyes.
Trabodenoson-treated eyes have significantly reduced optic nerve (ON) edema compared with vehicle-treated eyes. RGC counts are higher in Trabodenoson-treated eyes compared to vehicle (74% versus 47% of the contralateral eye).
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