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- 2025年12月05日
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- 文献和实验
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- 保存条件：
4°C, sealed storage, away from moisture
- 英文名：
VS-6062(hydrochloride)
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- 规格：
5 mg
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PF-562271 hydrochloride
CAS No. : 939791-41-0
MCE 国际站：PF-562271 hydrochloride
产品活性：PF-562271 (VS-6062) hydrochloride 是一种有效，可逆，ATP 竞争性的 FAK 和 Pyk2 激酶抑制剂，IC50 分别为 1.5 nM 和 13 nM。
研究领域：Protein Tyrosine Kinase/RTK
In Vitro: PF-562271 (VS-6062) hydrochloride is shown to be a 30- to 120-nM inhibitor of CDK2/E, CDK5/p35, CDK1/B, and CDK3/E in recombinant enzyme assays, in cell-based assays evaluating the role of CDKs, a 48-hour exposure of 3.3 μM PF-562271 is required to alter cell cycle progression. PF-562271 is potent in an inducible cell-based assay measuring phospho-FAK with a IC50 of 5 nM.
PF-562271, a selective inhibitor of both FAK and proline-rich tyrosine kinase 2 (PYK2), a FAK-related family member, on cell growth and colony formation in Ewing sarcoma cell lines. Seven cell lines are treated for 5 days with PF-562271 across a range of concentrations using 2-fold serial dilutions. Treatment with PF-562271 impaires cell viability in all cell lines, with an average IC50 of 2.4 μM after 3 days of treatment. TC32 and A673 are the 2 most sensitive cell lines, with IC50 concentrations of 2.1 and 1.7 μM, respectively.
In Vivo: PF-562271 inhibits FAK phosphorylation in vivo in a dose-dependent fashion (calculated EC50 of 93 ng/mL, total) after p.o. administration to tumor-bearing mice. Rats that receive PF-562271 demonstrate a decrease in tumor growth after 2 weeks of treatment with signs of bone healing as evidenced by the deposition of new bone (cortical and cancellous) at sites previously damaged by the tumor.
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文献和实验noworrynoworry 请问各位前辈，Pyk2（Pyk2信号通路)有特异性抑制剂吗？哪里能买到？ noworrynoworry 拜托各位，帮帮忙啊 diwen FAK/ Pyk2 tyrosine kinase inhibitor (PF-562271) http://lifesciences.b-bridge.com/products/detail/1440/PF
Protheroe(1969) ／崎等(1974) 田中等(1980) Sch／pf等(1980) 3／15 3／22 3／8 21／41 25／61 33／101 12／37
诊断，CD25是激活T，B细胞的标记，SmIg（细胞膜表面免疫球蛋白）和EM（小鼠红细胞受体）是B细胞成熟的特征性标志，CD19反应谱广，是鉴别全B系的敏感而又特异的标记。CD10，为诊断Common-ALL的必需标记，CyCD22用于检测早期B细胞来源的急性白血病是相当特异和敏感的，CD14，为单核细胞特有，抗髓过氧化物酶（MPO）为髓系特有，CD34为造血干细胞标记，CD38为造血祖细胞标志，CD41a，CD41b，CD61，血小板过氧化物酶（PPO）为巨核系特有，CyIg+，PC
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