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- 英文名：
VDP-green (NEP)
- 库存：
货期：14天
- 供应商：
MedChemExpress LLC
- CAS号：
2414276-32-5
- 规格：
电询
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NEP
CAS No. : 2414276-32-5
MCE 国际站：NEP
产品活性：NEP (VDP-green (NEP)) 是一种基于分子内电荷转移 (ICT) 机制的感应荧光探针，用于感应含邻二硫醇的蛋白质 (VDPs)。NEP 在活细胞和动物体内对 VDPs 表现出高选择性，并显示强绿色荧光信号 (λex/λem=430/535 nm)。NEP 具有用于帕金森氏症研究的潜力。
研究领域：Others
作用靶点：Fluorescent Dye
In Vitro: NEP (1-30 μM; 6 hours) has no or little cytotoxicity in HepG2 and PC12 cells.
NEP (10 μM; 4 hours) causes the fluorescence intensity to decrease gradually in PC12 cells pretreated with 6-OHDA (0, 50, 100, and 200 μM; for 30 min).
NEP contains a dithiarsolane moiety (five-membered As-S ring) as the receptor of VDPs. In the presence of VDPs, NEP displays a strong green fluorescence signal produced by the cyclic dithiarsolane cleavage and subsequent intramolecular cyclization to liberate the fluorophore. NEP maintains a reliable fluorescence response within the range of pH 7-10.
In Vivo: NEP (10 μM; for 4 h) causes the obvious green signal in zebrafishes (4 day old).
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文献和实验Sphingosine-1-Phosphate Signaling in Neural Progenitors
that human embryonic stem cell-derived neuroepithelial progenitor cells (hES-NEP) express functional S1P receptors. These cells can be further differentiated to a neuronal cell type, and therefore represent a good model system to study the role of S1
Isolation, Culture, and Differentiation of Progenitor Cells from the Central Nervous System
by diluting 0.1 mL of stock solution in 5 mL of sterile 1X PBS supplemented with Ca ++ and Mg ++ (Sigma D8662). Light inhibitory solution (LI) (prewarmed) Mice (embryonic or adult) NEP basal medium NEP basal medium containing 2%
数来自血液。大多数分子量70kDa，正常时不能从肾小球滤过，当滤过功能正常时尿酶增加主要反映肾小管间质损害，常作为监测药物肾毒性（氨基糖苷类抗菌素、抗肿瘤药物及锂制剂等）、肾移植排异反应以及各种肾小管间质疾病诊断的指标。近年发现，在中草药肾病患者中，当肾功能中度受累时，尿中神经内肽酶（NEP）浓度明显下降，至终末期肾衰时几乎为零。NEP浓度与尿中微量蛋白呈负相关，与肌酐清除率则呈正相关。 而来自肾实质本身的尿酶也是帮助定位诊断肾脏（尤其肾小管）损害的良好标记性物质。如N-乙酰-β-D-氨
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