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118174-38-2
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AhR modulator-1
CAS No. : 118174-38-2
MCE 国际站：AhR modulator-1
产品活性：AhR modulator-1 (compound 6-MCDF) 是一种选择性的口服活性芳烃受体 (AhR) 调节剂。AhR modulator-1 部分地通过在肿瘤形成之前抑制前列腺 VEGF 的产生而抑制肿瘤转移。AhR modulator-1 在大鼠子宫中也具有抗雌激素特性。
研究领域：Immunology/Inflammation | Protein Tyrosine Kinase/RTK | Vitamin D Related/Nuclear Receptor
作用靶点：Aryl Hydrocarbon Receptor | VEGFR | Estrogen Receptor/ERR
In Vitro: AhR modulator-1 (6-MCDF; 0.1-10 μM; 48-96 hours; ASPC-1 cells) treatment exhibits dose-dependent growth inhibitory effects with growth inhibitory effects of 26, 43 and 99% at concentrations of 0.1, 1 and 10 μM, respectively.
In Vivo: AhR modulator-1 (6-MCDF; 0-40 mg/kg; oral administration; daily; for 12 weeks; C57BL/6-Tg(TRAMP)8247Ng/J mice) treatment reduces the frequency of pelvic lymph node metastasis in mice fed the 40 mg/kg diet. And serum VEGF concentrations are also reduced. Prostate tumor incidence and size are not significantly reduced.
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文献和实验Ahr knockout genotyping by PCR
Bradfield Lab, McArdle Laboratory for Cancer Research, University of Wisconsin-Madison Medical School http://mcardle.oncology.wisc.edu/bradfield/Ahr-knockout.html This protocol is published in Journal
Ahr transgenic genotyping by PCR
Bradfield Lab, McArdle Laboratory for Cancer Research, University of Wisconsin-Madison Medical School http://mcardle.oncology.wisc.edu/bradfield/Ahr-transgenic-genotyping.html Amplify a 600bp fragment using OL638 and OL639
Cell-Based Assays for Identification of Aryl Hydrocarbon Receptor (AhR) Activators
The Ah receptor (AhR) is a ligand-dependent transcription factor that mediates a wide range of biological and toxicological effects from exposure to structurally diverse synthetic and naturally occurring chemicals. The role of the AhR
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