- ￥4466 - 6700
- MedChemExpress(MCE)
- 美国
- HY-13278
- 2025年07月07日
企业认证
相关产品推荐更多 >
万千商家帮你免费找货
0 人在求购买到急需产品
- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years. In solvent: -80°C, 6 months; -20°C, 1 month.
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
1012104-68-5
- 规格：
2 mg/5 mg
| 规格： | 2 mg | 产品价格： | ￥4466.0 |
|---|---|---|---|
| 规格： | 5 mg | 产品价格： | ￥6700.0 |
MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。
IRAK inhibitor 4
CAS No. : 1012104-68-5
MCE 国际站：IRAK inhibitor 4
产品活性：IRAK inhibitor 4 是白细胞介素-1 受体相关激酶-4 (IRAK4) 的抑制剂。
作用靶点：IRAK
In Vitro: Lack of IRAK-4 impairs the production of proinflammatory mediators by macrophages and DCs in response to M. bovis and M. tuberculosis. IRAK-4-/- cells stimulated with E. coli LPS display delayed activation kinetics of all signaling proteins analyzed, and exhibit dramatically reduced p65 phosphorylation. IRAK1/4 (20 μM) has an inhibitory effect on LPS mediated IL-6 production. IRAK1/4 inhibitor do not decrease p38 phosphorylation in AMs. Combination of IRAK1/4 and Rip2 inhibitors inhibits TLR2-mediated cytokine production in sarcoidosis PBMCs and AMs. IRAK4 is overexpressed and activated in T-ALL. IRAK4 mRNA level is elevated in T-ALL cells from patients compared with the levels detected in thymic T cells or T cells from peripheral blood.
In Vivo: IRAK-4-/- mice exhibit a greatly reduced survival rate following aerosol infection compared with IRAK-4+/+ or IRAK-4+/- mice. IRAK-4-/- mice show increased bacterial burden in all organs at 15, 30, and 60 d postinfection. MCL1, but not BCL-xL, overrides the therapeutic effects of combinatorial IRAK1/4 inhibitor and ABT-737 therapy in vivo.
相关产品：Zimlovisertib | Emavusertib | Ginsenoside Rb1 | JH-X-119-01 hydrochloride | IRAK-1-4 Inhibitor I | PROTAC IRAK4 degrader-1 | HS-276 | Zabedosertib | KT-474 | AZ1495 | HS-243 | IRAK inhibitor 2 | IRAK4-IN-7 | Edecesertib | JNJ-1013 | KTX-951 | IRAK inhibitor 1 | IRAK4-IN-4 | PF-06426779 | AS2444697 | IRAK4-IN-1 | KTX-582 | GLPG2534 | IRAK inhibitor 3 | IRAK-4 protein kinase inhibitor 2 | HS271 | IRAK inhibitor 4 (trans) | IRAK inhibitor 6 | IRAK4-IN-21
热门产品线：重组蛋白 | 化合物库 | 天然产物 | 荧光染料 | PROTAC | 同位素标记物
Trending products：Recombinant Proteins | Bioactive Screening Libraries | Natural Products | Dye Reagents | PROTAC | Isotope-Labeled Compounds
风险提示：丁香通仅作为第三方平台，为商家信息发布提供平台空间。用户咨询产品时请注意保护个人信息及财产安全，合理判断，谨慎选购商品，商家和用户对交易行为负责。对于医疗器械类产品，请先查证核实企业经营资质和医疗器械产品注册证情况。
文献和实验-5. Endothelial cells and activated fibroblasts produce IL-33, thus further amplifying local inflammatory responses. Abbreviations: CCL, CC-chemokine ligand; IL, interleukin; TGF, transforming growth factor; TH2 cell, type 2 T helper cell; TIMP, tissue inhibitor
, inhibitor of NFκ B; IRAK, IL-1R-associated kinase; LTA, lipoteichoic acid; NIK, NFκ B-inducing kinase; PGN, peptidoglycan; RIP, receptor-interacting protein; TNF, tumour necrosis factor; TNFR, TNF receptor; TRADD, TNFR1-associated protein with death domain
体（spliceosome），在其中，他们发现了一种叫做IRAK4的高活性蛋白质，这种蛋白质能将细胞送达引起癌症的狂乱之中。在试验中，他们靶向IRAK4的高活性形式来阻断其在AML细胞和移植到免疫抑制小鼠中的患者AML细胞中的功能，经过治疗，白血病细胞显著减少。据多机构研究的高级研究员、辛辛那提儿童医院医学中心癌症和血液疾病研究所的Daniel Starczynowski博士说，这也延长了动物模型的存活率。③华人学者发表《Nature Neuroscience》提示精神分裂症的高危基因范德堡大学的分子生理学和生物
技术资料暂无技术资料 索取技术资料
