IRAK-1-4 Inhibitor I,509093-47

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IRAK-1-4 Inhibitor I

CAS No. : 509093-47-4

MCE 国际站：IRAK-1-4 Inhibitor I

产品活性：IRAK-1-4 Inhibitor I 是 IRAK1/4 抑制剂，IC₅₀ 分别为 0.2 μM 和 0.3 μM。

研究领域：Immunology/Inflammation

作用靶点：IRAK

In Vitro: IRAK-1-4 Inhibitor I has IC₅₀ greater than the highest concentration tested (10 μM) against a panel of 27 other kinases, including the most closely homologous (outside of the IRAK family) Lck and pp60^SRC. Additionally, IRAK-1-4 Inhibitor I does not show any signs of cytotoxicity in a 72 h proliferation assay in HeLa cells (ED₅₀>30 μM). Significant inhibition of IRAK-1 is observed with IRAK-1-4 Inhibitor I (IRAK-1 IC₅₀=0.3 μM). IRAK-1/4 inhibitor eliminates the LPS-induced increases in Bcl10, NF-κB, and IL-8. IRAK-1/4 mediates LPS-induced IL-8 activation and functions upstream of Bcl10. The LPS-induced increase in Bcl10 declines by 73% (from 5.18±0.22 to 2.36±0.08 ng/mL), and the IL-8 response decline by 60% (from 2.64±0.31 to 1.14±0.08 ng/mL).

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