Cycloleucine

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Cycloleucine

CAS No. : 52-52-8

MCE 国际站：Cycloleucine

产品活性：Cycloleucine 是一种 S-腺苷甲硫氨酸介导的甲基化的特异性抑制剂。Cycloleucine 是 NMDA 受体甘氨酸变构位点的拮抗剂，K_i 值为 600 μM。Cycloleucine 在体外也是 ATP：L-蛋氨酸-S-腺苷基转移酶的竞争性抑制剂。Cycloleucine 具有抗焦虑和抑制细胞作用。

研究领域：Membrane Transporter/Ion Channel  |  Neuronal Signaling

作用靶点：iGluR

In Vitro: Cycloleucine (4-40 mM; 3 h) blocks internal methylation of viral RNA in B77 transformed chick embryo fibroblasts.
?Cycloleucine (40 mM; 24 h) blocks the formation of both m⁶A and the penultimate G^m in B77 38S RNA subunits by greater than 90%.
?Cytostatic (10 μg/mL) inhibits the viability human KB and mouse L1210s leukemia cell lines.

In Vivo: Cycloleucine (0.5-4 μg; intracerebroventrical injection) increases time spent in open arms, open arm entries, and extreme arrivals in rats.?Cycloleucine reduces thymus and spleen weights in Semliki Forest virus (SFV) strain A7(74) infected and control mice.

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