IRG1-IN-1,2407652-42-8

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IRG1-IN-1

CAS No. : 2407652-42-8

MCE 国际站：IRG1-IN-1

产品活性：IRG1-IN-1 是衣康酸衍生物。IRG1-IN-1 可以抑制免疫反应基因 1 (IRG1) 的活性。IRG1-IN-1 可用于癌症、炎症和自身免疫性疾病的研究。

研究领域：Others

作用靶点：Others

In Vitro: IRG1-IN-1(compound 6) (0.5 mM; 2 mM) reduces production of itaconic acid and the secretion of TNFα from LPS-stimulated human monocyte derived macrophages (hMDMs) .
IRG1-IN-1 (0.5 mM; 1 mM) inhibits the proliferation of C-IRG1-9 rat glioma cells.
IRG1-IN-1(10 nM) increases proliferation of TCR-activated hCD8⁺ T cells.
IRG1-IN-1(10μM) shows depletion of trimethylation of histone 3 at lysine 4 (H3K4me3) in CR-activated hCD8⁺ T cells.

In Vivo: IRG1-IN-1 (compound 6) (i.p.; 0.2 mg/kg; 27 days) shows antitumor effect in C57BL/6 mice.

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