GRI977143,325850-81-5

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GRI977143

CAS No. : 325850-81-5

MCE 国际站：GRI977143

产品活性：GRI977143 是特异性的 LPA₂ 受体的激动剂，其EC₅₀ 值为3.3 μM。

研究领域：GPCR/G Protein  |  Apoptosis

作用靶点：LPL Receptor  |  Caspase

In Vitro: GRI977143 (10 μM, 24-72 h) is effective in reducing activation of caspases 3, 7, 8, and 9 and inhibits poly(ADP-ribose)polymerase 1 cleavage and DNA fragmentation in different extrinsic and intrinsic models of apoptosis.
GRI977143 is an effective stimulator of extracellular signal-regulated kinase 1/2 activation and promotes the assembly of a macromolecular signaling complex consisting of LPA2, Na+-H+ exchange regulatory factor 2, and thyroid receptor interacting protein 6.

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