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- 2025年12月05日
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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 英文名：
(Z)-SU6668; (Z)-TSU-68
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- 规格：
10 mM * 1 mL/5 mg/10 mg/50 mg/100 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥660.0 |
|---|---|---|---|
| 规格： | 5 mg | 产品价格： | ￥375.0 |
| 规格： | 10 mg | 产品价格： | ￥600.0 |
| 规格： | 50 mg | 产品价格： | ￥1800.0 |
| 规格： | 100 mg | 产品价格： | ￥2700.0 |
MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。
(Z)-Orantinib
CAS No. : 210644-62-5
MCE 国际站：(Z)-Orantinib
产品活性：(Z)-Orantinib ((Z)-SU6668) 是一种有效，选择性，具有口服活性和 ATP 竞争性的 Flk‐1/KDR，PDGFRβ 和 FGFR1 抑制剂，IC50 值分别为 2.1，0.008 和 1.2 µM。(Z)-Orantinib 是有效的抗血管生成和抗肿瘤剂，可诱导已建立的肿瘤消退。
研究领域：Protein Tyrosine Kinase/RTK
In Vitro: SU6668 (5-15 min) inhibits Flk-1 trans-phosphorylation (Ki=2.1 μM), FGFR1 trans-phosphorylation (Ki=1.2 μM), and PDGFR autophosphorylation (Ki=0.008 μM).
SU6668 (0.03-10 μM; 60 min) inhibits the VEGF-stimulated increase of KDR tyrosine phosphorylation in HUVECs.
SU6668 inhibits mitogenesis of HUVECs induced by both VEGF and FGF in a dose-dependent manner with IC50s of 0.34 and 9.6 μM, respectively.
In Vivo: SU6668 (4-200 mg/kg/day; p.o. for 21 d) induces dose-dependent inhibition of A431 tumor growth in athymic mice.
SU6668 (75 mg/kg/day; i.p. for 22 d) significantly suppresses tumor angiogenesis and vascularization in mice.
SU6668 (200 mg/kg/day; p.o. for 11-27 d) induces striking regression of large established A431 xenografts in athymic mice.
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文献和实验亦称Z带（ Z-band）、 Z板（ Z-disc）、 Z线（ Z-line）。指横纹肌 I带中央部所见到的膜状构造。 Z膜将肌原纤维按横向隔开，从一个 Z膜到邻近的 Z膜成为一个形态单位，称为肌（原纤维）节。 I微丝在 Z膜处截开，分别和 4条棒状 Z微丝相连。
E.Z.N.Z.TM MicroElute RNA Clean-up Protocol
实验步骤 1. Measure the volume of sample and adjust the sample volume to 100ul with DEPC-Water and proceed to step 2. 2. Add 350ul QVL Lysis buffer and mix by vortexing at maximum speed for 15 seconds. When process small
E.Z.N.Z.TM MicroElute RNA Desalting and Concentration protocol
实验步骤 1. Measure the volume of sample and transfer into a new 1.5 ml microcentrifuge tube. Adjust the sample volume to 100ul with DEPC-Water and proceed to step 2. Note: if the starting samples is RNA pellet, dissolve
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