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- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years. In solvent: -80°C, 6 months; -20°C, 1 month.
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
1311367-27-7
- 规格：
10 mM * 1 mL/100 mg/2 mg/5 mg/10 mg/50 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥2219.0 |
|---|---|---|---|
| 规格： | 100 mg | 产品价格： | 询价 |
| 规格： | 2 mg | 产品价格： | ￥1200.0 |
| 规格： | 5 mg | 产品价格： | ￥2200.0 |
| 规格： | 10 mg | 产品价格： | ￥3400.0 |
| 规格： | 50 mg | 产品价格： | ￥9000.0 |
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BIX 02565
CAS No. : 1311367-27-7
MCE 国际站：BIX 02565
产品活性：BIX 02565 是一种有效的核糖体 S6 激酶 2 (RSK2) 抑制剂，IC50 为 1.1 nM。
研究领域：MAPK/ERK Pathway
作用靶点：Ribosomal S6 Kinase (RSK)
In Vitro: BIX 02565, a potent RSK2 inhibitor (IC50=1.1 nM) targets for the treatment of heart failure secondary to myocardial infarction through indirect NHE inhibition. BIX 02565, a second Rsk inhibitor, protects enzyme active sites from reaction with biotinylated nucleotide acyl phosphates.
In Vivo: In telemetry-instrumented rats, BIX 02565 (30, 100, and 300 mg/kg p.o. QD for 4 days) elicits concentration-dependent decreases in MAP after each dose (to -39±4 mm Hg on day 4 at Tmax). BIX 02565 produces concentration-dependent relaxation ex vivo in the phenylephrine-constricted rat aortic ring at concentrations above 0.03 μM with a calculated EC50 of 3.1 μM. Subsequently, BIX 02565 is infused in the anesthetized rat in a low-dose (0.1, 0.3, and 1.0 mg/kg per 20 min) and high-dose (1.0, 3.0, and 10.0 mg/kg per 20 min) series of continuous infusions to test the effect of compound on hemodynamics in vivo.
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文献和实验Using RepeatMasker to Identify Repetitive Elements in Genomic Sequences
RECON Web site http://bix.ucsd.edu/repeatscout/
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