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- 2025年12月05日
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- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
2375281-44-8
- 规格：
10 mM * 1 mL/1 mg/5 mg/10 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥5280.0 |
|---|---|---|---|
| 规格： | 1 mg | 产品价格： | ￥1138.0 |
| 规格： | 5 mg | 产品价格： | ￥2820.0 |
| 规格： | 10 mg | 产品价格： | ￥4044.0 |
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NF-κΒ activator 2
CAS No. : 2375281-44-8
MCE 国际站：NF-κΒ activator 2
产品活性：NF-κΒ activator 2 是一种有效和具有口服活性的 NF-ҡB 激活剂，EC50 值为 1.58 μM。NF-κΒ activator 2 通过增加 NF-κB 的表达和激活来诱导 SOD2。NF-κΒ activator 2 可用于肌萎缩性侧索硬化症 (ALS) 的研究。
研究领域：NF-κB
作用靶点：NF-κB
In Vitro: NF-κΒ activator 2 (compound 61) (1 μM, 6 h) induces SOD2 mRNA expression in SH-SY5Y neuroblastoma cells.
In Vivo: NF-κΒ activator 2 (1 mg/kg; i.v.) displays a suitable half-life (0.96 h) in mice.
NF-κΒ activator 2 (5 mg/kg; p.o.) displays a comparable half-life (2.86 h), oral bioavailability (15.6%), and Cmax (92 ng/mL).
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文献和实验transcription activator?like effector nucleases (TALENs) are broadly useful tools for performing targeted genome editing in a wide variety of organisms and cell types including plants, zebrafish, C. elegans , rat, human somatic cells, and human pluripotent stem
RANKL-Based Osteoclastogenic Assays from Murine Bone Marrow Cells
or indirectly. This protocol describes a procedure for generating osteoclasts from mouse bone marrow cells using macrophage colony stimulating factor and receptor activator of NF-κB ligand.
activation motif; JAK, Janus kinase; NFκB, nuclear factor κB; PKB, protein kinase B; PLC, phospholipase C; SIGIRR, single Ig IL-1-related receptor; sIL-1RAcP, soluble IL-1 receptor accessory protein; sST2, soluble ST2; STAT3, signal transducer and activator
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