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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 英文名：
GSK 9089
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
95167-41-2
- 规格：
10 mM * 1 mL/5 mg/10 mg/50 mg/100 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥660.0 |
|---|---|---|---|
| 规格： | 5 mg | 产品价格： | ￥600.0 |
| 规格： | 10 mg | 产品价格： | ￥1000.0 |
| 规格： | 50 mg | 产品价格： | ￥3500.0 |
| 规格： | 100 mg | 产品价格： | ￥5500.0 |
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DY131
CAS No. : 95167-41-2
MCE 国际站：DY131
产品活性：DY131 (GSK 9089) 是一种有效的选择性的 ERRγ 和 ERRβ 激动剂，对 ERRα，ERα 和 ERβ 无效。DY131 还抑制 Smo 信号传导。
研究领域：Vitamin D Related/Nuclear Receptor | Stem Cell/Wnt
作用靶点：Estrogen Receptor/ERR | Smo
In Vitro: DY131 (0.1-30 μM; 5 days) treatment suppresses cell proliferation and reduces BrdUrd-positive cells in both LNCaP-ERRγ and LNCaP cells in a dose-dependent manner, with higher suppression in LNCaP-ERRγ clone.
DY131inhibits Shh induced accumulation of Smo::EGFP with an IC50 of 0.8 μM. DY131 suppresses SAG (100 nM) induced accumulation of Smo::EGFP in the primary cilium and Gli transcription activity with an IC50 of ~2 μM.
DY131 dramatically decreases phosphorylated histone H3 (pH3) marked proliferation of CGNPs induced by Shh.
A selective ERRγ agonist, DY131, inhibits the growth of the ERα-positive endometrial cancer cells but promoted that of the ERα-negative cancer cells.
In Vivo: DY131 (5 μg/kg; subcutaneous injection; every second day; for 12 days) treatment increases P450 side-chain cleavage (P450scc), StAR and HMGCoA reductase (HMGCR) while decreases hormone sensitive lipase (HSL) expressions.
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文献和实验1、放射性核素衰变表3H35S32P125I131I时间(年)剩余活性(%)时间(年)剩余活性(%)时间(年)剩余活性(%)时间(年)剩余活性(%)时间(年)剩余活性(%)194.5298.4195.3495.50.298.3289.3596.1290.8891.20.496.6384.41092.3386.51287.10.695.0479.81588.7482.51683.11.091.8575.42085.3578.52079.41.687.2671.32582.0674.82475
4.3(3.7～5.0) 4.7*(3.5～5.8) 血清钾均值范围 毫当量/升 131(126～155) 158(155～165) 131(129～149) 145*(130～155) 血清钾均值范围 毫当量/升 4.0(3.1～5.2) 7.0(5.6～8.0) 5.1(3.8～6.4) 10.1*(8.4～12.2) 血清钾均值范围 毫当量/升 104(94～110)
生理学数据--实验动物红细胞总数、压积、体积、大小和血红蛋白浓度
.0～30) 32.0 23.0 鸽 3.2 42.3 131.0 6.9～13.2 12.8 30.0 40.0 鸡 2.8(2.0～3.2) 35.6(24～43.3) 127(120～137) 6.8～11.2 10.3(7.3～12.9) 29（27～30） 36.6(33～41) 鸭 2.8 39.5 ～ 6.6～12.8 14.8(9～21) 38.1 51.2(32～71)
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