1532-24-7

Telomerase Inhibition and Telomere Targeting in Hematopoietic Cancer Cell Lines with Small Non-Nucleosidic Synthetic Compounds (BIBR1532)

BIBR1532 that is a selective, non-nucleosidic inhibitor of the catalytic component hTERT. Treatment of cancer cells with this compound leads to progressive telomere shortening, consecutive telomere dysfunction, and finally growth arrest after a lag

Isolation of Human and Mouse Neutrophils Ex Vivo and In Vitro

peroxide, superoxide anion, and nitric oxide. Recent studies have demonstrated a new strategy—so-called neutrophil extracellular traps (NETs) that are able to kill bacteria and fungi in vivo and in vitro (Brinkmann et al., Science 303:1532–1535, 2004

Screening of Telomerase Inhibitors

(G-quadruplex-interactive compound), BIBR1532 (non-nucleosidic reverse transcriptase inhibitor), 2′-O-methyl RNA, and peptide nucleic acids (PNAs; hTR antisense oligonucleotides). To determine minimal effective concentrations for telomerase inhibition