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- 详细信息
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- 文献和实验
- 技术资料
- 英文名：
Rat hepatic stellate cells
- 库存：
50万
- 供应商：
齐氏生物
- 肿瘤类型：
无
- 细胞类型：
原代细胞
- 品系：
SD RAT
- 组织来源：
肝
- 相关疾病：
正常
- 物种来源：
大鼠
- 免疫类型：
不详
- 细胞形态：
星型
- 器官来源：
肝脏
- 年限：
成年
- 生长状态：
贴壁
- 是否是肿瘤细胞：
否
- 运输方式：
冻存/快递
- 规格：
5×105
肝星状细胞（Hepatic Stellate Cells) 是各种致纤维化因素的最终靶细胞，正常情况下肝星状细胞处于静止状态，当肝脏受到炎症或机械刺激等损伤时，肝星状细胞被激活，其表型由静止型转变为激活型。
应用方向：
1）HSC与肝纤维化
2）HSC与肝脏发育和再生
3）HSC与肝肿瘤
4）HSC与免疫系统
用户反馈：
（上图为药企研发部门提供）
2016-2019 论文引用（部分）：
- Deng M, Xu L, Xie X et al., .Downregulation of syndecan‑1 expression induces activation of hepatic stellate cells via the TGF‑β1/Smad3 signaling pathway. Mol Med Rep. 2019; 20(1):368-74.
- Zhang F, Lu S, He J et al., Ligand activation of PPARγ by ligustrazine suppresses pericyte functions of hepatic stellate cells via SMRT-mediated transrepression of HIF-1α. Theranostics 2018; 8(3): 610-26.
- Zhang F, Jin H, Wu L et al., Diallyl trisulfide suppresses oxidative stress-induced activation of hepatic stellate cells through production of hydrogen sulfide. Oxid Med Cell Longev. 2017; 2017:1406726.
- Lian N, Jin H, Zhang F et al., Curcumin inhibits aerobic glycolysis in hepatic stellate cells associated with activation of adenosine monophosphate‐activated protein kinase. IUBMB Life. 2016; 68(7):589-96.
- He L, Hou X, Fan F et al., Quercetin stimulates mitochondrial apoptosis dependent on activation of endoplasmic reticulum stress in hepatic stellate cells. Pharm Biol. 2016,; 54(12):3237-43.
- Zhang F, Lu C, Xu W et al., Curcumin raises lipid content by Wnt pathway in hepatic stellate cell. J Surg Res. 2016; 200(2): 460-6.
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文献和实验- Deng M, Xu L, Xie X et al., .Downregulation of syndecan‑1 expression induces activation of hepatic stellate cells via the TGF‑β1/Smad3 signaling pathway. Mol Med Rep. 2019; 20(1):368-74.
- Zhang F, Lu S, He J et al., Ligand activation of PPARγ by ligustrazine suppresses pericyte functions of hepatic stellate cells via SMRT-mediated transrepression of HIF-1α. Theranostics 2018; 8(3): 610-26.
- Zhang F, Jin H, Wu L et al., Diallyl trisulfide suppresses oxidative stress-induced activation of hepatic stellate cells through production of hydrogen sulfide. Oxid Med Cell Longev. 2017; 2017:1406726.
- Lian N, Jin H, Zhang F et al., Curcumin inhibits aerobic glycolysis in hepatic stellate cells associated with activation of adenosine monophosphate‐activated protein kinase. IUBMB Life. 2016; 68(7):589-96.
- He L, Hou X, Fan F et al., Quercetin stimulates mitochondrial apoptosis dependent on activation of endoplasmic reticulum stress in hepatic stellate cells. Pharm Biol. 2016,; 54(12):3237-43.
- Zhang F, Lu C, Xu W et al., Curcumin raises lipid content by Wnt pathway in hepatic stellate cell. J Surg Res. 2016; 200(2): 460-6.
Isolation and Culture of Hepatic Stellate Cells
, viable, freshly isolated hepatic stellate cells from rat liver. This two-step protocol (collagenase/pronase digestion and Nycodenz gradient) yields a preparation of approx 4–5 �107 cells enriched in 74% HSC having a viability of at least 76% as estimated
Isolation and Characterization of Hepatic Stem Cells, or Oval Cells, from Rat Livers
The pace of research on the potential therapeutic uses of liver stem cells or “oval cells” has accelerated significantly in recent years. Concurrent advancements in techniques for the isolation and characterization of these cells have helped
Isolation of Hepatic Progenitor Cells from the Galactosamine-Treated Rat Liver
Oval cells and small hepatocytes (SHs) are well known as hepatic stem/progenitor cells. However, the relationship between the oval cells and SHs in liver regeneration is not well understood. To resolve this issue, we established a technique
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