Killer Cell Immunoglobulin Lik

产品名称：Killer Cell Immunoglobulin Like Receptor 2DS2 (KIR2DS2) Antibody-Killer Cell Immunoglobulin Like Receptor 2DS2 (KIR2DS2) Antibody

产品货号：abx032610

产品规格：80ul#400ul

应用类型：WB, IHC, FCM

保存建议：Killer Cell Immunoglobulin Like Receptor 2DS2 (KIR2DS2) Antibody-Killer Cell Immunoglobulin Like Receptor 2DS2 (KIR2DS2) Antibody建议收到产品后，储存温度为-20°C。避免重复冻融

背景资料：Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several 'framework' genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response.

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关键词：Killer Cell Immunoglobulin Like Receptor 2DS2 (KIR2DS2) Antibody，Killer Cell Immunoglobulin Like Receptor 2DS2 (KIR2DS2) Antibody，待更新