Tyrosine-Protein Phosphatase N

产品名称：Tyrosine-Protein Phosphatase Non-Receptor Type 1 (PTPN1) Antibody-Tyrosine-Protein Phosphatase Non-Receptor Type 1 (PTPN1) Antibody

产品货号：abx001339

产品规格：20ul#50ul#100ul#200ul

应用类型：WB, IHC, IF/ICC

保存建议：Tyrosine-Protein Phosphatase Non-Receptor Type 1 (PTPN1) Antibody-Tyrosine-Protein Phosphatase Non-Receptor Type 1 (PTPN1) Antibody建议收到产品后，储存温度为-20°C。避免重复冻融

背景资料：PTPN1 Antibody is a Rabbit Polyclonal antibody against PTPN1. The protein encoded by this gene is the founding member of the protein tyrosine phosphatase (PTP) family, which was isolated and identified based on its enzymatic activity and amino acid sequence. PTPs catalyze the hydrolysis of the phosphate monoesters specifically on tyrosine residues. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP has been shown to act as a negative regulator of insulin signaling by dephosphorylating the phosphotryosine residues of insulin receptor kinase. This PTP was also reported to dephosphorylate epidermal growth factor receptor kinase, as well as JAK2 and TYK2 kinases, which implicated the role of this PTP in cell growth control, and cell response to interferon stimulation. Two transcript variants encoding different isoforms have been found for this gene.

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关键词：Tyrosine-Protein Phosphatase Non-Receptor Type 1 (PTPN1) Antibody，Tyrosine-Protein Phosphatase Non-Receptor Type 1 (PTPN1) Antibody，待更新