Anti-Peripherin, clone 7C5; 30

Anti-Peripherin, clone 7C5

Peripherin is a ~57kDa intermediate filament subunit found initially in sensory neurons of the peripheral nervous systems. Subsequently it was found in some sensory and other neurons of the central nervous system and also in PC12 cells. Peripherin is also expressed in certain neuroendocrine tumors and in the insulin producing cells of the pancreas. Peripherin belongs to the Class III family of intermediate filament subunits which includes vimentin, glial fibrillary acidic protein (GFAP) and desmin. Antibodies to peripherin can be used in identifying, classifying, and studying neurons throughout the nervous system. Peripherin is also a good diagnostic marker for ballooned axons seen in Lou Gehrig's disease (Amyotrophic lateral sclerosis) and some neuronally derived tumors. Autoantibodies to peripherin are frequently seen in the sera of patients with diabetes. Peripherin is not related to peripherin/RDS, a protein of the photoreceptor outer membrane mutations of which are causative of certain forms of slow retinal degeneration.

7C5

Peripherin, class III neuronal intermediate filament protein. By western blot, the antibody detects a band migrating at approximately 57 kDa corresponding to peripherin;

reactive with human, bovine, porcine and rat peripherin by western blot, other species not tested.

• Western Blotting
• Immunohistochemistry

Immunocytochemistry 1:100. The integrity of the epitope recognized by this antibody is not affected by aldehyde-based fixatives as 8G2; light fixations are still preferred; not tested in paraffin embedded tissue sections.

Immunoblotting 1:1,000; 57kDa

Optimal working dilutions must be determined by end user.

• Bovine
• Human
• Pig
• Rat

IgG1κ

Recombinant rat peripherin.

POSITIVE CONTROL: Sensory neurons of the central or peripheral nervous system; PC12 cells

Purified immunoglobulin in PBS containing no preservative.

Maintain at -20°C in undiluted aliquots for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles.

• PRPH
• PRPH1
• Peripherin.
• peripherin
• NEF4

Neuroscience

• Sensory & PNS
• Neuronal & Glial Markers

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Chemicon (Millipore)

Culture Supernatant

Mouse

0.5 mg/mL

Monoclonal Antibody