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Anti-Alzheimer Precursor Prote

in A4, a.a. 66-81 of APP {N-terminus}, clone 22C11; 100 μL
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  • 询价
  • MAB348-100UL
  • 2025年07月14日
  • Immunofluorescence;Western Blotting
  • Mouse
  • Canine;Human;Mouse;Monkey
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    • 详细信息
    • 文献和实验
    • 技术资料
    • 应用范围：

      Immunofluorescence;Western Blotting

    • 宿主：

      Mouse

    • 适应物种：

      Canine;Human;Mouse;Monkey

    • 抗原来源：

      0

    • 库存：

      大量

    • 是否单克隆：

      1

    • 规格：

      100 μL

    Species Reactivity Key Applications Host Format Antibody Type
    H, M, R, Mk, Po, F IF, IH, IH(P), WB Mouse Ascites Monoclonal Antibody
    Description:
    Anti-Alzheimer Precursor Protein A4, a.a. 66-81 of APP (N-terminus), clone 22C11
    Background Information:
    Amyloid Precursor Protein (APP) is expressed in the brain, kidney, heart, and spleen of fetal tissues; it is induced during neuronal differentiation. The most-substantiated role for APP is in synaptic formation and repair; its expression is upregulated during neuronal differentiation and after neural injury. In adult brain, highest expression of APP is found in the frontal lobe of the cortex. Moderate expression is observed in the cerebellar cortex, the posterior perisylvian cortex-opercular gyri and the temporal associated cortex. Defects in APP are a cause of autosomal dominant Alzheimer's disease (AD). Deposits of amyloid protein in senile plaques near nerve processes are found in the brains of aged humans and in cases of Alzheimer's disease. The principle component of this extracellular amyloid is beta/A4, a 4 kDa peptide derived from the larger APP. The creation, transport and function of these proteins are currently under investigation.
    Alternate Names:
    APP
    Clone:
    22C11
    Specificity:
    Reacts with pre-A4. The antibody recognizes a N-terminal epitope on the pre-A4 molecule
    Key Applications:
    • Immunofluorescence
    • Immunohistochemistry
    • Immunohistochemistry (Paraffin)
    • Western Blotting
    Application Notes:
    Immunohistochemistry:
    Previous lot tested Immunohistochemistry on 4% paraformaldehyde/15% picric acid perfused and fixed, frozen and paraffin embedded sections.

    Optimal working dilutions must be determined by the end user.
    Species Reactivity:
    • Human
    • Mouse
    • Rat
    • Monkey
    • Pig
    • Fish
    Isotype:
    IgG1
    Immunogen:
    Purified recombinant Alzheimer precursor A4 (pre A4695) fusion protein.
    Epitope:
    a.a. 66-81 of APP (N-terminus)
    Control:
    Brain tissue.
    Presentation:
    Unpurified ascites mouse monoclonal IgG1 containing no preservatives.
    Storage Conditions:
    Stable for 1 year at -20ºC from date of receipt.
    Gene Symbol:
    • APP
    • PN-II
    • AD1
    • ABETA
    • CTFgamma
    • APPI
    • ABPP
    • A4
    • CVAP
    • PN2
    • PreA4
    • AAA
    Quality Assurance:
    Evaluated by immunohistochemistry(paraffin) on Alzheimer’s Disease-Hypothalamus Tissue.

    Immunohistochemistry(paraffin):
    Amyloid (β-A4-protein, cat. # MAB348) staining on Alzheimer’s Disease-Hypothalamus. Tissue pretreated with Citrate, pH 6.0. The antibody was diluted to 1:80, using IHC-Select® Detection with HRP-DAB. Immunoreactivity is seen as staining on plaque deposits (dark brown) or as cerebral vascular amyloid deposition in the walls of blood vessels (brown).
    Antibody Category:
    Neuroscience
    Antibody Sub-Category:
    Neurodegenerative Diseases
    Usage Statement:
    Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    Trade Name:
    Chemicon (Millipore)
    Format:
    Ascites
    Host:
    Mouse
    Concentration:
    Variable
    Antibody Type:
    Monoclonal Antibody

    更多产品技术资讯，请访问密理博中国博客：http://blog.milliporechina.com

    Purified recombinant Alzheimer precursor A4 (pre A4695) fusion protein. 详细描述见链接：http://www.millipore.com/catalogue/item/MAB348-100UL

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    图标文献和实验
    相关实验

    • 大脑的秘密生活

      [3]Zhang YW，Thompson R，Zhang H，et al．APP processing in Alzheimer's disease．Mol Brain，2011，4:3． [4]Sastre M，Steiner H，Fuchs K，et al．Presenilin-dependent gamma-secretes processing of beta-amyloid precursor protein at a site corresponding to the S3

    • Studies of the Ubiquitin Proteasome System

      and equipment for maintenance of insect cell cultures and generation of recombinant baculovirus (Murphy et al., 2004 ) and batch ( protocol 22 ) or column ( protocol 23 ) purification of APP‐BP1 and Uba

    • Transvascular delivery of small interfering RNA to the centr

      hairpin precursor transcripts into ∼22 nucleotide regulatory RNAs via consecutive cleavages by two RNase III enzymes, Drosha and Dicer. In this study, we characterize Drosophila small RNAs that derive from short intronic hairpins termed “mirtrons

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