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- 2025年12月05日
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- 详细信息
- 技术资料
- 保存条件：
polypeptide, sealed storage, away from moisture and light
- 英文名：
Glucagon-like peptide-1 (GLP-1)(7-36), amide TFA; Human GLP-1 (7-36), amide TFA
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- 规格：
500 μg/1 mg/5 mg
| 规格： | 500 μg | 产品价格： | ￥1200.0 |
|---|---|---|---|
| 规格： | 1 mg | 产品价格： | ￥2000.0 |
| 规格： | 5 mg | 产品价格： | ￥6000.0 |
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GLP-1(7-36), amide TFA
MCE 国际站：GLP-1(7-36), amide TFA
产品活性：GLP-1(7-36), amide TFA 是一种主要的肠道激素，在葡萄糖的刺激下，它能促使胰岛 β 细胞分泌胰岛素。
研究领域：GPCR/G Protein
作用靶点：Glucagon Receptor
In Vitro: Cells treated with phorbol 12-myristate 13-acetate for 2 h has significantly higher active GLP-1(7-36) Acetate (Human GLP-1-(7-36)-amide Acetate) concentrations in the media than those in the control. The glucose treatment also increases active GLP-1 secretion from cells in dose-dependent manner. Palmitic, oleic, linoleic or linolenic acid dose-dependently stimulated active GLP-1 secretion from cells. Active GLP-1 secretion is significantly greater with unsaturated fatty acids such as oleic, linoleic and linolenic acids than with palmitic acid. The treatment of NCI-H716 cells with CPE dose-dependently increases active GLP-1 concentrations in the media. A 37% increase is observed in active GLP-1 secretion from these cells at a concentration of 0.1 % CPE.
In Vivo: Gastric administration of glucose increases active GLP-1(7-36) amide levels in the portal blood after 10 min, followed by a marked decrease at 30 min. The gastric administration of TO also increases active GLP-1 levels after 10 min, and followed by a decrease to basal levels at 60 min. Individually, glucose and TO increase the secretion of GLP-1 in a dose-dependent manner. Furthermore, the co-administration of glucose and TO additively increase peak GLP-1 levels. CPE-administered mice have higher active GLP-1 levels in the portal blood at 10 and 30 min than those in the control mice. When glucose is administered with CPE, active GLP-1 and insulin levels in the portal blood are slightly higher in CPE-administered mice than in the control mice. High-fat diet-fed C57BL/6J mice develop hyperglycaemia and impair glucose tolerance.
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