Bradykinin,6846-03-3

Bradykinin acetate 产品活性：Bradykinin acetate 是一种有效的内皮依赖性血管扩张剂，可降低血压。Bradykinin acetate 可引起支气管和肠道非血管平滑肌的收缩，增加血管通透性，并参与疼痛的机制。 产品来源： www.medchemexpress.cn/bradykinin-acetate.html 研究领域：GPCR/G Protein | Metabolic Enzyme/Protease 作用靶点：Bradykinin Receptor | Endogenous Metabolite | Ser/Thr Protease In Vitro: Bradykinin acetate is a potent vasodilator peptide that exerts its vasodilatory action through stimulation of specific endothelial B2 receptors, thereby causing the release of prostacyclin, NO, and EDHF. Bradykinin acetate has been reported to be involved in the progression of many types of cancer. Bradykinin acetate treatment promotes the invasion and migration of colorectal cancer cells. Bradykinin acetate treatment stimulates ERK1/2 activation and IL-6 production. Exogenous bradykinin acetate markedly inhibits TF expression in mRNA and protein level induced by LPS in a dose-dependent manner. The NO synthase antagonist L-NAME and PI3K inhibitor LY294002 dramatically abolish the inhibitory effects of bradykinin acetate on tissue factor expression. In Vivo: Application of 1 μM bradykinin acetate to the ovary produces significant decreases in heart rate and mean arterial pressure. In vagotomized animals, application of 1 μM bradykinin acetate to the ovary produces bradycardia and hypotension similar to the responses evoked when vagal innervation is intact.Vascular bradykinin acetate can improve pancreatic microcirculation and hemorheology in rats with severe acute pancreatitis. The pancreatic microcirculatory blood flow volume and velocity in the vascular bradykinin acetate treatment group increase gradually after 48 h.PI3K/Akt signaling pathway activation induced by bradykinin administration reduces the activity of GSK-3β and MAPK, and reduces NF-x03BA; B level in the nucleus, thereby inhibiting TF expression. Consistent with this, intraperitoneal injection of C57/BL6 mice with bradykinin also inhibits the thrombus formation induced by ligation of inferior vena cava. 相关产品：Rapamycin | 3-Methyladenine | Acetylcysteine | 5-Fluorouracil | ATP | Retinoic acid | Hydrocortisone | Estradiol | Nicotinamide | Prostaglandin E2 | AICAR | Palmitic acid | Docetaxel | Isoprenaline hydrochloride | L-Ascorbic acid | Cytarabine | Melatonin | Calcitriol | Capsaicin | Arachidonic acid | Valproic acid | Oleic acid | β-Nicotinamide mononucleotide | Acetaminophen | Biotin | Corticosterone | Lactate | Cholesterol | NAD+ | DHEA