- ￥600 - 660
- MedChemExpress(MCE)
- 美国
- HY-B1488
- 2025年12月05日
企业认证
相关产品推荐更多 >
万千商家帮你免费找货
0 人在求购买到急需产品
- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
4°C, stored under nitrogen, away from moisture
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
1684-40-8
- 规格：
10 mM * 1 mL/100 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥660.0 |
|---|---|---|---|
| 规格： | 100 mg | 产品价格： | ￥600.0 |
MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。
Tacrine hydrochloride
CAS No. : 1684-40-8
MCE 国际站：Tacrine hydrochloride
产品活性：Tacrine hydrochloride 是一种 AChE 和 BChE 的有效抑制剂，IC50 值分别为 31 nM 和 25.6 nM 。Tacrine hydrochloride 也是 NMDAR 的抑制剂， IC50 值为 26 μM。Tacrine hydrochloride 可用于研究阿尔茨海默氏症。
研究领域：Neuronal Signaling | Membrane Transporter/Ion Channel
作用靶点：Cholinesterase (ChE) | iGluR
In Vitro: Tacrine (12.5-37.5 nM) inhibits venom acetylcholinesterase as well as human serum butyrylcholinesterase in a concentration-dependent manner.
Tacrine reduces the neurotoxicity induced by the activation of the NMDARs in murine cortical neuronal cultures with an IC50of ~500 μM.
Tacrine inhibits the NMDAR responses in a concentration-dependent manner with an IC50 of ~190 μM at -60 mV.
In Vivo: Tacrine (20-40 μmol/kg; s.c.) disrupts retention of learning in 17- and 30-day old mice in passive avoidance, and while the low dose of tacrine treatment (5 μmol/kg; s.c.) improves retention in 17-day old mice.
Tacrine (0.1-0.4 mg/mL; i.p. for 7 d) inhibits the expression of AChE, but does not significantly improve the protection of the retina function and morphology in mice.
相关产品：Drug Repurposing Compound Library Plus | FDA-Approved Drug Library Plus | FDA-Approved Drug Library Mini | Bioactive Compound Library Plus | Membrane Transporter/Ion Channel Compound Library | Neuronal Signaling Compound Library | FDA-Approved Drug Library | CNS-Penetrant Compound Library | Drug Repurposing Compound Library | Neurotransmitter Receptor Compound Library | FDA Approved & Pharmacopeial Drug Library | Anti-Alzheimer's Disease Compound Library | Neuroprotective Compound Library | Anti-Parkinson's Disease Compound Library | Neurodegenerative Disease-related Compound Library | Antidepressant Compound Library | Heterocyclic Compound Library | Pain-Related Compound Library | Off-patent Drug Library | Membrane Protein-targeted Compound Library | Membrane Receptor-targeted Compound Library | Ion Channel Compound Library | Corticosterone | D-AP5 | Dizocilpine maleate | NMDA | L-Glutamic acid | Evans Blue | CNQX | Kynurenic acid | Glycine | NBQX | Cycloleucine | Donepezil Hydrochloride | L-Phenylalanine | Quinolinic acid | α-NETA | TMPyP4 tosylate | Galanthamine | Garcinol | Physostigmine salicylate | Memantine hydrochloride | Ifenprodil tartrate | D-Cycloserine | Scopoletin | Rivastigmine | DNQX | Ro 25-6981 Maleate | Protopine | Ibotenic acid
热门产品线：重组蛋白 | 化合物库 | 天然产物 | 荧光染料 | PROTAC | 同位素标记物
Trending products：Recombinant Proteins | Bioactive Screening Libraries | Natural Products | Dye Reagents | PROTAC | Isotope-Labeled Compounds
风险提示：丁香通仅作为第三方平台，为商家信息发布提供平台空间。用户咨询产品时请注意保护个人信息及财产安全，合理判断，谨慎选购商品，商家和用户对交易行为负责。对于医疗器械类产品，请先查证核实企业经营资质和医疗器械产品注册证情况。
文献和实验、药理等方面研究的不断深入，使得AD的药物治疗学开始有了一些进展，逐渐发现了一些供临床选用的药物。由于人们普遍认为AD的主要原因是胆碱能不足，因而胆碱能加强剂是目前的主要研究对象。 目录 • AChE抑制剂 • M受体激动药 • 神经细胞生长因子增强药 • 代谢激活药 AChE抑制剂 编辑本段 回目录 他克林 Tacrine
6 × 106 6 × 106 1684 2154
【共享】某机构发表的核酸相关研究的文章（EST,SNP等），PDF全文下载
Hettmann T, Siddiqui RA, von Langen J, Frey C, Romao MJ, Diekmann S (2003) Mutagenesis study on the role of a lysine residue highly conserved in formate dehydrogenases and periplasmic nitrate reductases Biochem Biophys Res Commun 310: 40-47 pdf Junker
技术资料暂无技术资料 索取技术资料
