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- 保存条件：
4°C, sealed storage, away from moisture
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
2921-88-2
- 规格：
50 mg/100 mg
| 规格： | 50 mg | 产品价格： | ￥550.0 |
|---|---|---|---|
| 规格： | 100 mg | 产品价格： | ￥750.0 |
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Chlorpyrifos
CAS No. : 2921-88-2
MCE 国际站：Chlorpyrifos
产品活性：Chlorpyrifos 是一种神经毒性杀虫剂，属于亚硫磷酯。Chlorpyrifos 还是一种 AChE 抑制剂，可影响昆虫，人类和其他动物的神经功能。Chlorpyrifos 干扰细胞复制和细胞分化，最终改变神经元中的突触神经传递。
研究领域：Neuronal Signaling
作用靶点：Cholinesterase (ChE)
In Vitro: Chlorpyrifos mediates desulfuration to produce chlorpyrifos oxon (CPO), which has higher affinity toward the active site of serine-dependent ester hydrolases such as AChE.
Chlorpyrifos (3.9-250 μM; 24-72 h) is toxic to oligodendrocyte progenitors.
Chlorpyrifos toxicity is associated with (7.5-480 μM; 18 h) nuclear condensation and elevation of caspase 3/7 activity, (60 μM; 2, 4 h) Heme oxygenase-1 mRNA expression in Central Glia (CG-4) cells, and (30, 60, 120 μM; 24 h) enhances H2DCF-DA intensity.
In Vivo: Chlorpyrifos (97-276 mg/kg; p.o.; single dose) has moderately acute oral toxicity, with lethal dose, 50% (LD50) of 97-276 mg/kg in rats.
Chlorpyrifos (1 mg/kg and 5 mg/kg for 1 mL/kg; s.c.; once daily for 3 d) has adverse effect on learning and memory abilities of rats, and affects pregnant rats on gestational days 9-12, results offspring behavioral abnormalities.
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