Antitumor agent-75,2827065-29-

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Antitumor agent-75

CAS No. : 2827065-29-0

MCE 国际站：Antitumor agent-75

产品活性：Antitumor agent-75 是一种新型有效的抗肿瘤剂。Antitumor agent-75 对癌症和正常人类细胞系具有细胞毒性作用。Antitumor agent-75 与 Antitumor agent-74 (HY-151292) 结合使用时对人肺腺癌（细胞系 A549 ）具有高度选择性的细胞毒作用，其 IC₅₀ 值为 2.8 μM。Antitumor agent-75 可用于癌症的研究。

研究领域：Others

作用靶点：Others

In Vitro: Antitumor agent-75 (14da) shows a highly selective cytotoxic effect (combined with 13da, mrBIQ 13da/14da) against human lung adenocarcinoma (cell line A549) with an IC₅₀ value of 2.8 μM.
Antitumor agent-75 (1, 5, 25, 50, 100μM; 0-48 h) (mriBIQ 13da/14da) has the cytotoxic effect in A549 cells.
Antitumor agent-75 (1, 2.5, and 5 μM; 12 h) (mriBIQ 13da/14da) has the mechanism of the cytotoxic effect on A549 cells may be associated with the stopping of the cell cycle in phase S and inhibition of DNA synthesis as well as with the induction of mithochondrial apoptosis.
Antitumor agent-75 (1, 2.5 and 5 μM) increases the production of reactive oxygen species (ROS) and induces mitochondrial apoptosis in A549 cells.

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