K 01-162,677746-25-7

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

K 01-162

CAS No. : 677746-25-7

MCE 国际站：K 01-162

产品活性：K 01-162 (K162) 抑制 Aβ 肽纤维的形成并消除其神经毒性。K 01-162 与 Aβ₄₂ 多肽结合，EC₅₀ 值为 80 nM。K 01-162 直接与 AβO 结合，KD 值为 19 μM。K 01-162 能够穿透大脑，可用于阿尔茨海默症的研究。

研究领域：Neuronal Signaling

作用靶点：Amyloid-β

In Vitro: K 01-162 (1 μM; 24 h) reduces the level of intracellular AβO.
K 01-162 (0.78-50 μM; 5 min) blocks the synaptic binding activity of AβO in mouse hippocampal neurons.

In Vivo: K 01-162 (100 μM; intracerebroventricular infusion 0.25 μL/h for 2 weeks) attenuates amyloid load in vivo.

相关产品：Bioactive Compound Library Plus  |  Neuronal Signaling Compound Library  |  Anti-Alzheimer's Disease Compound Library  |  Neurodegenerative Disease-related Compound Library  |  Targeted Diversity Library  |  Membrane Protein-targeted Compound Library  |  DAPT  |  β-Amyloid (25-35)  |  Thioflavin T  |  β-Amyloid (1-42), human TFA  |  FPS-ZM1  |  Colivelin TFA  |  Rutin  |  Azeliragon  |  20(S)-Ginsenoside Rg3  |  Ginsenoside Rg1  |  β-Amyloid (1-42), (rat/mouse)  |  Tolcapone  |  Geniposide  |  Methoxy-X04  |  Emrusolmin  |  Semagacestat  |  Ginsenoside Re  |  Aducanumab  |  Notoginsenoside R1  |  Bavachinin  |  Licochalcone B  |  Hoechst 34580 tetrahydrochloride  |  β-Amyloid (1-40)  |  Direct Blue 1  |  Leucomethylene blue mesylate  |  Valiltramiprosate  |  Glimepiride  |  Hematoxylin  |  Chemerin-9 (149-157) (TFA)

热门产品线：重组蛋白  |  化合物库  |  天然产物  |  荧光染料  |  PROTAC  |  同位素标记物

Trending products：Recombinant Proteins  |  Bioactive Screening Libraries  |  Natural Products  |  Dye Reagents  |  PROTAC  |  Isotope-Labeled Compounds