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- 2025年12月05日
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- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
209984-57-6
- 规格：
10 mM * 1 mL/1 mg/5 mg/10 mg/25 mg/50 mg/100 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥1089.0 |
|---|---|---|---|
| 规格： | 1 mg | 产品价格： | ￥450.0 |
| 规格： | 5 mg | 产品价格： | ￥990.0 |
| 规格： | 10 mg | 产品价格： | ￥1650.0 |
| 规格： | 25 mg | 产品价格： | ￥2790.0 |
| 规格： | 50 mg | 产品价格： | ￥4152.0 |
| 规格： | 100 mg | 产品价格： | ￥5900.0 |
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LY-411575
CAS No. : 209984-57-6
MCE 国际站：LY-411575
产品活性：LY-411575 是高效的 γ-secretase 抑制剂，能够抑制 Aβ40 蛋白的产生，其 IC50 值为 0.078 nM/0.082 nM（基于膜/细胞），同时抑制 Notch 分裂，IC50 值为 0.39 nM。
研究领域：Neuronal Signaling | Stem Cell/Wnt | Apoptosis
作用靶点：γ-secretase | Notch | Apoptosis
In Vitro: LY-411,575 blocks Notch activation, and results in apoptosis in primary and immortalized KS cells. LY-411,575 (500 μM) induces G2/M growth arrest SLK cells. LY411575 treatment significantly decreases the amounts of intracellular HCV RNA with IC50 of 0.56 ± 0.20 μM and extracellular HCV particles. LY411575 (0-40 nM) alone or in combination with BMS-790052 (0-40 pM) decreases supernatant infectious titers in a dose-dependent manner, and is synergistic regarding production of infectious virus. LY411575 (10 µM) treatment impairs ROS production in HCVcc-infected cells. LY411575 significantly attenuates EMT by inhibiting the Notch signaling activation in vitro.
In Vivo: LY-411,575 (10 mg/kg) decreases brain and plasma Aβ40 and -42 robustly when chronically administered to TgCRND8 mice. LY411,575 reduces cortical Aβ40 in young transgenic CRND8 mice (ED50 appr 0.6 mg/kg) and produces significant thymus atrophy and intestinal goblet cell hyperplasia at higher doses (>3 mg/kg). The extent of intestinal goblet cell hyperplasia induced by LY411,575 (10 mg/kg) is similar in young and aged mice. LY411575 inhibits mouse proliferative vitreoretinopathy (PVR) formation in vivo.
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文献和实验zhanghaopeng 有几个问题想在此请教。 1.在做免疫组化和Western时，观察ERK分子的变化是不是要先测定总ERK，而后在分别测定pERK1/2呢？可否推荐一款可以做组化和Western的一抗（我做的是小鼠）。 2.关于Notch通路的研究如果受到条件、经费的限制是否可以单纯观测NICD的表达，以证明Notch的活化？ 3.看到Notch通路的阻断剂有很多，例如DAPT、LY411575等等，可否推荐一下哪款比较好、且可以侧
Generation of Antibodies to Cell Surface Markers on Mature Natural Killer Cells
receptor from all strains of mice. For example, 5E6 binds to Ly49C and/or I from B6, C3H, and NZB strains, but fails to react with any NK cells of 129, C57BR, C58, or FVB mice. Besides Ly49 receptors, NKR-P1 receptor gene products (NKR-P1B) also contain
鼠品系如C57BL/6、NZB、CE等，此外CD161在某些T细胞亚群中也有表达。小鼠CD56 mAb并不与小鼠NK细胞反应。最近报道有一新的mAb DX5可与所有品系NK细胞反应。此外，CD122（IL- 2Rb ）、CD161a和Ly49家族（Klra,Killer cell lectin- like receptor）等标记也可用于NK的鉴定。4. Mf /Mo和DC细胞 抗Ly- 71 mAb F4/80广泛应用于小鼠组织中Mf 的分布和功能研究，此mAb与Eo、DC也有反应。小鼠CD14（rmC
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