YM90K,154164-30-4

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YM90K

CAS No. : 154164-30-4

MCE 国际站：YM90K

产品活性：YM90K 是一种有效的选择性的 AMPA 受体拮抗剂，K_i 为 84 nM。YM90K 抑制海藻酸酯 (K_i 为 2.2 μM) 和 NMDA (K_i 为 37 μM) 受体的效力较低，并具有神经保护作用。

研究领域：Membrane Transporter/Ion Channel  |  Neuronal Signaling

作用靶点：iGluR

In Vitro: YM90K co-injected with AMPA or kainate into the rat striatum protect cholinergic neurons against AMPA- or kainate-induced neurotoxicity.

In Vivo: YM90K shows potent suppressive activity against audiogenic seizure in DBA/2 mice; ED₅₀ values of YM90K against tonic seizure is 2.54 mg/kg (i.p.). The duration of the anticonvulsant effects of YM90K is 30 min.
In a global ischemia model, YM90K (15 mg/kg i.p.) significantly prevents the delayed neuronal death in the hippocampal CA1 region in Mongolian gerbils when administered 1 h after 5-min ischemia. The therapeutic time window for the neuroprotective effect of YM90K (30 mg/kg i.p.) is 6 h.
In a focal ischemia model, YM90K (30 mg/kg i.v. bolus+10 mg/kg/h for 4 h) reduces the volume of ischemic damage in the cerebral cortex in F344 rats.

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