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4°C, sealed storage, away from moisture
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货期：1-2天
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MedChemExpress LLC
- CAS号：
582-46-7
- 规格：
1 mg
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Terrein
CAS No. : 582-46-7
MCE 国际站：Terrein
产品活性：Terrein 是一种黑色素生成抑制剂。Terrein 诱导乳腺癌细胞凋亡 (apoptosis)。Terrein是铜绿假单胞菌 (Pseudomonas aeruginosa) 中的群体感应和 c-di-GMP 抑制剂。
研究领域：GPCR/G Protein | Neuronal Signaling | Apoptosis | Anti-infection
作用靶点：Melanocortin Receptor | Apoptosis | Antibiotic
In Vitro: Treatment of Mel-Ab cells with Terrein (10-100 µM) for 4 days significantly reduces melanin levels in a dose-dependent manner. Terrein reduces melanin synthesis by reducing tyrosinase production via ERK activation.
Terrein (5-500 µM; 24 and 48 hours) reduces the viability of these cells in concentration- and time-dependent manners.
Terrein (150, 250, 500µM; 24 hours) induces programmed cell death in both invasive and non-invasive breast cancer cell lines. Thus, the optimal non-toxic concentrations of Terrein (25 and 75 µM) were used for subsequent experiments.
Terrein (25 and 75 µM) significantly decrease the mRNA levels of both MMP-2 and MMP-9 in MDA-MB-231 cells. Terrein (75 µM) significantly decrease the mRNA levels of both MMP-2 and MMP-9 in MCF-7 cells.
Terrein (75 µM) inhibits the expression of RhoA, RhoB, p-Rac1 in MCF-7 cells. Terrein (75 µM) inhibits the expression of RhoB, p-Rac1 in MDA-MB-231 cells.
Terrein (10, 30, and 100 μM) inhibits the production of virulence factors such as elastase, pyocyanin, and rhamnolipid, as well as biofilm formation in P. aeruginosa PAO1 and PA14 strains.
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文献和实验., and Stern, D. B. (2000) Processing and degradation ofchloroplast mRNA. B io c h im ie 82, 573-582. 3. Barkan, A. and Goldschmidt-Clermont, M. (2000) Participation of nuclear genesin chloroplast gene expression. B io c h im ie 82, 559-572. 4. Sun,
in mature form (potential). domain 46 118 ig-like c2-type domain. domain 146 204 ig-like c2-type domain. domain 232 297 ig-like c2-type domain. disulfid 53 111 disulfid 153 197 disulfid 239 290 carbohyd 40 40 carbohyd 66 66 carbohyd 136 136
; pH = 8.0 (store at 4o C). Conc. Stock %(w/w) 50 ml 100 ml 150 ml 250 ml EDTA 0.5 M 372.3g/M 16.98 9.31g 18.62g 27.92g 46.55g NaOH ~0.5 M 40g/M 1.82 1.014g 2.028g 3.042g
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