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- 文献和实验
- 技术资料
- 保存条件：
Please store the product under the recommended conditions in the Certificate of Analysis.
- 英文名：
Kefurox
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
55268-75-2
- 规格：
50 mg/100 mg
| 规格： | 50 mg | 产品价格： | ￥3890.0 |
|---|---|---|---|
| 规格： | 100 mg | 产品价格： | ￥6230.0 |
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Cefuroxime
CAS No. : 55268-75-2
MCE 国际站：Cefuroxime
产品活性：Cefuroxime 是一种具有口服活性的第二代头孢菌素抗生素 (antibiotic)，增加了对 β-内酰胺酶 (β-lactamase) 的稳定性。Cefuroxime 具有广谱的抑制活性，对革兰氏阳性菌和革兰氏阴性菌都有效。
研究领域：Anti-infection
作用靶点：Bacterial | Antibiotic
In Vitro: Cefuroxime is highly active against S. aureus (MIC=0.25 μg/ml), regardless of whether the strains produces a penicillinase. It is against Staphylococcus aureus methicillin susceptible; S. aureus, methicillin resistant, Streptococcus pyogenes, S. pneumoniae, S. viridans, S. faecalis, and Clostridium spp with MIC values of 0.25 μg/ml, 5.9 μg/ml, 0.125 μg/ml, 0.125 μg/ml, 0.125 μg/ml, >125.0 μg/ml, and 1.2 μg/ml, respectively.
Cefuroxime (10-100 μg/ml; 2-6 hours) rapidly bactericidal, its action is comparatively slow against the strains of S. aureus, but, even so, over 99% of the initial inoculum is killed by 6 h. The gram-negative organisms are killed rapidly, and in most cases over 99% of the very large inocula are killed within 2 h; the β-lactamase-producing strains are killed as quickly as non-enzyme-producing strains.
In Vivo: Rabbits (weighing 2.0 to 2.5 kg) are challenged intravenously with S. aureus strain 630 (a penicillinase-producing strain), the median effective dose of Cefuroxime is 3 mg/kg as a result of the protection test.
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文献和实验呋辛 cefuroxime - 96 33 0.94 0.19 1.7 苯丁酸氮芥 chlorambucil 87 chloramphenicol 75～90 25 53 2.4 0.94 4.0 氯喹 chloroquine 89 61 61 1.8 115 41 氯噻嗪 chlorothiazide 9～56 92 94.6 4.5 0.20 1.5 氯丙嗪 chlorpromazine 32 〈1 95～
，儿童50～100mg/kg/日，分4次服。 头孢羟氨苄（cefadroxil）成人2g/日，分2次服；儿童30～60mg/kg/日，分2～3次服。 头孢孟多（cefamandole）成人2～4g/日，儿童50～100mg/kg/日，分3～4次肌内注射。静脉注射成人8～12g/日，儿童100～200mg/kg/日，分2～4次。 头孢呋辛（cefuroxime）肌内注射，成人2～2.5g/日，儿童30～60mg/kg/日，分3～4次。静脉注射，成人4.5～6g/日，儿童50～
曲松 ceftriaxone - 46 90～95 0.24 0.16 7.3 头孢呋辛 cefuroxime - 96 33 0.94 0.19 1.7 苯丁酸氮芥
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