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Androgen Receptor & Co-Transcription Factors: AR,ELK1,FOS,JUN,NFKB1,NFKB2,REL,RELA,SP1,SRF.
Up-Regulated by Androgen Receptor: ABHD2,ALDH1A3(RALDH3),APPBP2,CAMKK2,CENPN,CYP2U1,DBI,DHCR24,EAF2,ENDOD1,ERRFI1,FZD5,GUCY1A1,HERC3,HPGD,IGF1R,KLK2 (hGK-1, hK2),KLK3,KLK4,KRT8,LIFR,LRIG1,LRRFIP2,NCAPD3,NFKBIA (IκBα, MAD3),NKX3-1,ORM1,PAK1IP1,PGC,PIAS1, PMEPA1,RAB4A,SEC22C,SGK1,SLC45A3,SMS,SNAI2, SPDEF,STEAP4,STK39, TIPARP,TPD52,TSC22D1 (TGFB1I4),VAPA,ZBTB10,ZBTB16.
Down-Regulated by Androgen Receptor: IGFBP5,MT2A,MYC,PIK3R3,TRIB1,TSC22D3.
Regulated by Androgen Receptor: ABCC4, ACKR3,ACSL3,ADAMTS1,CITED2,ELL2,FKBP5,IRS2,MAF, MAP7D1,MME,NDRG1,ORM2,OTULINL,PLPP1,RHOU,SLC26A2,SORD,TMPRSS2,VIPR1,WIPI1,ZNF189.
Cell Cycle: NCAPD3.
Chemokines: ACKR3.
Metabolism: ACSL3,ALDH1A3 (RALDH3),CYP2U1,DBI,DHCR24,HPGD,PLPP1,SMS,SORD.
Cell Proliferation & Differentiation & Apoptosis: ELL2,IGFBP5,LRIG1,MAF,NDRG1,STEAP4.
Proteases & Protease Inhibitors: ADAMTS1,KLK2 (hGK-1, hK2),KLK3,KLK4,MME,PGC,TMPRSS2.
Signal Transduction: CAMKK2,CITED2,ERRFI1,FKBP5,FZD5,GUCY1A1,HERC3,IGF1R,IRS2,LIFR,NFKBIA (IκBα, MAD3),PAK1IP1,PIK3R3,PMEPA1,TPD52,VIPR1.
Stress Responses: LRRFIP2,ORM1,ORM2,SGK1,STK39.
Cell Adhesion & Motility: KRT8,MAP7D1,RHOU.
Transcriptional Regulation: CENPN,EAF2,MAF,MYC,NKX3-1,PIAS1,SNAI2,SPDEF,TRIB1, TSC22D1(TGF
B1I4), TSC22D3,ZBTB10,ZBTB16,ZNF189.
Transporters & Trafficking Proteins: ABCC4,APPBP2,FKBP5,MT2A, RAB4A,SEC22C,SLC26A2, SLC45A3, VAPA, WIPI1.
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文献和实验Automated Microscopy and Image Analysis for Androgen Receptor Function
Systems-level approaches have emerged that rely on analytical, microscopy-based technology for the discovery of novel drug targets and the mechanisms driving AR signaling, transcriptional activity, and ligand independence. Single cell
浅析染色质免疫沉淀（ChIP）技术在 DNA 与蛋白质相互作用研究中的重要性
染色质免疫沉淀（ChIP）是研究蛋白质-DNA 相互作用的一项强大技术，广泛用于多个领域的染色质相关蛋白的研究（如组蛋白及其异构体，转录因子等），特别适用于已知启动子序列或整个基因位点的组蛋白修饰分析研究。这项技术采用特定抗体来富集存在组蛋白修饰或者转录调控的 DNA 片段，通过多种下游检测技术（定量 PCR ，芯片，测序等）来检测此富集片段的 DNA 序列。 ChIP 技术自诞生之后，已成功的应用于人或动物细胞和组织 [1] 、植物组织 [2] 、酵母 [3] 以及细菌、质粒
Practical Techniques for Detection of Toll-Like Receptor-4 in the Human Intestine
The human intestine has evolved in the presence of a diverse array of luminal microorganisms. In order to maintain intestinal homeostasis, mucosal immune responses to theses microorganisms must be tightly regulated. The intestine needs
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