emfret特约代理商|M011-1 GPVI

Ligand-Binding Assays for Collagen

deficient in one of these proteins (1 ,2 ). Integrin α2 β1 was found to be the major receptor responsible for platelet adhesion to collagen (3 ,4 ). The other collagen receptor, GPVI, was indicated to contribute to platelet activation and aggregation

Platelet Receptor Shedding

. There has been an increased focus on new methods for analyzing shedding of platelet glycoprotein (GP)Ib-IX-V and GPVI because these receptors are platelet specific and are critical for the initiation of platelet adhesion and activation in thrombus formation at arterial shear

Endogenous Inhibitory Mechanisms and the Regulation of Platelet Function

-associated GPVI platelet–collagen interactions and GPCR-mediated signalling and in positive regulation of “outside-in” integrin αIIb β3 -mediated signalling), intracellular inhibitory receptors (retinoic X receptor, glucocorticoid receptor, peroxisome