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文献和实验FLT3 Mutations in Acute Myeloid Leukemia
The prevalence of an internal tandem duplication (ITD) of the juxtamembrane domain-coding sequence and a missense mutation of D835 within the kinase domain of the FLT3 gene is 15–35% and 5–10% of adults with acute myeloid leukemia (AML
Identification of Murine and Human Acute Myeloid Leukemia Stem Cells
. The first evidence for both malignant hierarchy and CSCs came from studies on acute myeloid leukemia (AML) (1 , 2 ) followed by mounting evidence in other types of cancer ( 3 –5 ) . Murine models of leukemia have been the proving ground for the elucidation of key
Molecular Diagnosis of Acute Myeloid Leukemia with Maturation, FAB-Type M2
) (q22;q22) is consistently associated with acute myeloid leukemia with maturation (French-American-British classification subtype M2; AML-M2). It accounts for 40% of pediatric type AML-M2 Molecular cloning of the chromosome 8–21 translocation
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