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文献和实验Polyclonal Expansion of Human CD4+CD25+ Regulatory T Cells
Based on results from experimental animal models, the adoptive transfer of CD4+ CD25+ FOXP3+ regulatory T cells (Treg) is expected to be efficacious in treating autoimmune and inflammatory diseases, as well as in preventing alloresponses
Naturally occurring CD4+ CD25+ T regulatory cells originate from the thymus and play a central role regarding the maintenance of peripheral tolerance by suppression of autoreactive T-cell populations. However, T regulatory cells
Natural and Induced T CD4+CD25+FOXP3+ Regulatory T Cells
with their T cell receptor. They are specific for self-antigens. Adaptive or induced CD4+CD25+Foxp3+ regulatory T cells stem from mature CD4+CD25-Foxp3-precursors at the periphery following adequate stimulation. They have been shown to develop in vivo following
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