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文献和实验in such cell death. By introducing human cDNA encoding a nuclear form of 8-oxoG DNA glycosylase (hOGG1-1a) into immortalized mouse embryo fibroblasts lacking Ogg1 gene, we established a cell line which selectively accumulates 8-oxoguanine in mitochondrial DNA
Matched Cultures of Keratinocytes and Fibroblasts Derived from Normal and NER-Deficient Mouse Models
The uppermost layer of our skin, the epidermis, is formed largely of keratinocytes which constitute the skin’s major barrier function and the first line of defence against environmental physical, chemical and biological agents. The subsequent
Method: Maintaining Lymphoblastoid Cell Lines
. Cultures can be split when the cell count is 2.0 x million viable cells/ml. References: Human Genetic Mutant Cell Repository, Coriell Institute for Medical Research, Camden,New Jersey, Assurance Form, and Optimum method for passing lymphocyte
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