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文献和实验Transcriptional Regulation of UDP-Glucuronosyltransferases
Recent evidence has been provided that five nuclear receptors (NRs), (pregnane X receptor [PXR], constitutive androstane receptor [CAR], farnesoid X receptor [FXR] and peroxisome proliferator-activated receptor [PPARα and γ]) regulate
Materials: agarose solution in TBE or TAE (generally 0.7-1%) 1X TBE or TAE (same buffer as in agarose) gel loading dye
The Use of Hepatocytes to Investigate UDP-Glucuronosyltransferases and Sulfotransferases
. This system theoretically expresses the full complement of drug-metabolizing enzymes associated with the endoplasmic reticulum (CYP and UDP-glucuronosyltransferases) or located in the cytosolic compartment (sulfotransferases), and relevant accessory proteins required
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