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Functional Analysis of Human D1 and D5 Dopaminergic G Protein-Coupled Receptors: Lessons from Mutagenesis of a Conserved Serine Residue in the Cytosol

In mammals, dopamine G protein-coupled receptors (GPCR) are segregated into two categories: D1-like (D1R and D5R) and D2-like (D2Rshort , D2Rlong , D3R, and D4R) subtypes. D1R and D5R are primarily coupled to stimulatory heterotrimeric GTP

Determination of Benzoic Acid in Serum or Plasma by Gas Chromatography-Mass Spectrometry (GC/MS)

within a therapeutic range. In the gas chromatography method described, the drug from the acidified serum or plasma sample is extracted using ethyl acetate. The organic phase containing drug is separated and dried under a stream of nitrogen

Sci Adv: 最新突破，南开大学邵一鸣教授团队发现两种HIV-1广谱中和抗体

呈现出多种角度的结合方式。 438-B11/438-D5 的结构生物学解析图片来源：Science Advances 为探究 438-D5 和 438-B11 在 HIV 包膜蛋白 Env 识别过程中是否发生构象变化，研究团队随后分别在 2.05 Å 和 2.70 Å 的分辨率下测定和解析了未结合形式的 438-B11 和 438-D5 的晶体结构，证实 HCDR 是 438-B11 和 438-D5 具有高效广谱中和能力的结构基础。此外，438-B11/D5 HCDR3 中的二硫键对 HCDR