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- Sigma-Aldrich
- 进口
- R2625-50MG
- 2025年07月11日
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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
−20°C
- 保质期：
根据瓶身LOT号查询
- 英文名：
Retinoic acid
- 库存：
有现货
- 供应商：
浙江羽翔生物科技有限公司
- CAS号：
302-79-4
- 规格：
50MG
属性
生物来源
synthetic (organic)
检测方案
≥98% (HPLC)
形式
powder
技术
cell culture | mammalian: suitable
颜色
yellow
mp
180-181 °C (lit.)
溶解性
chloroform: 50 mg/mL
储存温度
−20°C
SMILES字符串
CC1=C(\C=C\C(C)=C\C=C\C(C)=C\C(O)=O)C(C)(C)CCC1
InChI
1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/b9-6+,12-11+,15-8+,16-14+
InChI key
SHGAZHPCJJPHSC-YCNIQYBTSA-N
一般描述
Furthermore, RA and other retinoids can also inhibit cellular proliferation and stimulate tyrosinase activity in a human melanoma cell line, while also inhibiting cell-substrate adhesion and motility in melanocytes. ATRA plays a vital role in the formation of the mammalian vascular system. Specifically, it regulates endothelial cell proliferation and vascular remodeling throughout tissue angiogenesis.
应用
- 视黄酸（RA）已用于胚胎干细胞至运动神经元的分化。
- 它已用于非洲爪蟾外胚层至胰腺的分化。
- 它还用于研究由RARα (视黄酸受体α)引起的表观遗传学调控。
- 它已用于研究原初精原细胞向精母细胞转化的RA信号转导。
生化/生理作用
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文献和实验Integrity of zinc finger motifs in PML protein is necessary for inducing its degradation by antimony.
Antimony (Sb) belongs to the same group as arsenic (As) in the periodic table, and both share similar characteristics. However, Sb2O3 (SbIII) has no methylation capacity, unlike arsenic trioxide (As2O3). In the present study, we determined the effect of SbIII on NB4 cells and found that antimony could induce PML-RARα fusion protein degradation, reorganization of PML-NBs, and NB4 cell differentiation with low cytotoxicity. On the other hand, zinc finger motifs in PML protein are considered to be a key target binding site for arsenic-induced PML-RARα protein degradation. Interestingly, antimony and arsenic lost their ability to degrade PML-RARα fusion protein in NB4 cells following pretreatment with phenanthroline (i.e., chelator of zinc ions), indicating that the integrity of zinc finger motifs in PML-RARα fusion protein is a fundamental condition for inducing the protein's degradation by antimony and arsenic. Moreover, we found that SbIII could not induce mutant PML (e.g., A126V and L218P) solubility change and degradation, similar to As2O3. In contrast, we found that the organic antimony compound phenylstibine oxide (PSO) could induce mutant PML protein degradation. In conclusion, our results indicate that SbIII might also be a promising agent to treat acute promyelocytic leukemia, in the same manner as As2O3.
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